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Proteintech
GCAP1 Polyclonal Antibody
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Product Details
12944-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GCAP1 Fusion Protein Ag4017 (1-201 aa encoded by BC031663)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNVMEGKS VEELSSTECH QWYKKFMTEC PSGQLTLYEF RQFFGLKNLS PSASQYVEQM FETFDFNKDG YIDFMEYVAA LSLVLKGKVE QKLRWYFKLY DVDGNGCIDR DELLTIIQAI RAINPCSDTT MTAEEFTDTV FSKIDVNGDG ELSLEEFIEG VQKDQMLLDT LTRSLDLTRI VRRLQNGEQD EEGADEAAEA AG (1-201 aa encoded by BC031663)
Target Information
Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cone dystrophy 3; GCAP 1; Guanylate cyclase activator 1A; guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; Guanylyl cyclase-activating protein 1
Gene Aliases: C6orf131; COD3; CORD14; GC-A; GCAP; GCAP-1; GCAP-I; GCAP1; GUCA; GUCA1; GUCA1A; mGCAP1
UniProt ID: (Human) P43080, (Mouse) P43081
Entrez Gene ID: (Human) 2978, (Mouse) 14913, (Rat) 301233
signal transduction
visual perception
phototransduction
regulation of signal transduction
positive regulation of cGMP-mediated signaling
positive regulation of guanylate cyclase activity
cellular response to calcium ion
positive regulation of cGMP biosynthetic process
regulation of guanylate cyclase activity
response to stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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