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This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.
2610034E13Rik; 2610529E18Rik; ACID1; Activator interaction domain-containing protein 1; activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC92; BVSYS; CMT2B2; DKFZp434K0512; ESTM2; hypothetical protein LOC406793; LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 25; MED25; Mediator complex subunit 25; mediator of RNA polymerase II transcription subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog; mediator of RNA polymerase II transcription, subunit 9 homolog; MGC70671; mMED25; P78; prostate-derived protein 78 kDa; PTOV2; RGD1305137; TCBAP0758; zgc:63555
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