NABP1 Antibodies

Target Information

NABP1, also known as NABP1/Ssb2, is a single-stranded DNA-binding protein involved in genome maintenance and stability. The gene encoding NABP1 is regulated by RORgamma2, a retinoid-related orphan receptor critical for thymopoiesis. Research has demonstrated that NABP1 plays a compensatory role in thymic maturation, particularly in conditions where its homolog, SSB1, is knocked out. Despite SSB1’s vital role in neonatal survival, NABP1 remains non-essential for thymic maturation and male fertility, indicating partial functional redundancy between these proteins. Furthermore, studies on the C-terminal regions of NABP1 have shown distinct roles in nucleic acid binding, contributing to DNA and RNA metabolism. These findings highlight NABP1’s importance in genomic integrity and its complex interplay within cellular processes.

Synonyms

4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik; AI852561; hSSB2; Nabp1; Nbp1; nucleic acid binding protein 1; nucleic acid-binding protein 1; Obfc2a; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; RGD1306658; Sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSS complex subunit B2; SOSS-B2; Ssb2