NLK Antibodies

Antibodies that detect NLK can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target NLK in Human, Mouse and Rat samples. Our NLK polyclonal, recombinant monoclonal and... Antibodies that detect NLK can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target NLK in Human, Mouse and Rat samples. Our NLK polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These... Antibodies that detect NLK can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target NLK in Human, Mouse and Rat samples. Our NLK polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to NLK. Find the NLK antibody that fits your needs. Choose from 1 of 17 NLK antibodies, which have been validated in experiments with 42 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been... Antibodies that detect NLK can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target NLK in Human, Mouse and Rat samples. Our NLK polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to NLK. Find the NLK antibody that fits your needs. Choose from 1 of 17 NLK antibodies, which have been validated in experiments with 42 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

NLK is a serine/threonine kinase involved in signal transduction and cellular communication. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors.

Synonyms

AI194375; LAK1; nemo like kinase; nemo-like kinase; NLK; Protein LAK1; RGD1561602; serine/threonine protein kinase NLK; serine/threonine-protein kinase NLK

NLK Antibodies

Target Information

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