Polycystin 1 Antibodies

Target Information

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Synonyms

Autosomal dominant polycystic kidney disease 1 protein; autosomal dominant polycystic kidney disease 1 protein homolog; mFLJ00285; PBP; PC1; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; polycystin 1, transient receptor potential channel interacting; polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1