RUNX1/RUNX2 Antibodies

Target Information

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.

Synonyms

Acute myeloid leukemia 1 protein; acute myeloid leukemia 3 protein; AKV core binding factor; AML1; AML1-EVI-1; AML1-EVI-1 fusion protein; AML3; AMLCR1; Cbf; CBF2alpha; Cbfa1; Cbfa-1; Cbfa2; CBF-alpha-1; CBF-alpha-2; CCD; CCD1; CLCD; core binding factor alpha 1; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; EVI-1; LS3; Oncogene AML-1; oncogene AML-3; Osf2; OSF-2; Osteoblast-specific transcription factor 2; PEA2aA; PEA2-alpha A; PEA2-alpha B; PEBP2 alpha A; Pebp2a; Pebp2a1; Pebp2a2; PEBP2aA; PEBP2aB; PEBP2alpha; PEBP2-alpha A; PEBP2-alpha B; Pebpa2a; Pebpa2b; Polyomavirus enhancer-binding protein 2 alpha A subunit; polyomavirus enhancer-binding protein 2 alpha B subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt related transcription factor 1; runt related transcription factor 2; runt-related transcription factor 1; Runt-related transcription factor 2; Runx1; RUNX1/ZNF687 fusion; Runx2; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; transcription factor