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mGluR1/5 (Group I) Glutamate Receptor Monoclonal Antibody (N75/33)

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mGluR1/5 (Group I) Glutamate Receptor Monoclonal Antibody (N75/33)

Product Details

75-116

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
-

Immunomicroscopy (IM)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N75/33

Immunogen

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession number P31424) produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; GPCR family C; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5 homolog; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGluR5f; mGluR5g; mGluR5h; mGluR5i; mGlurR1a; protein phosphatase 1, regulatory subunit 85; protein phosphatase 1, regulatory subunit 86; unnamed protein product

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Gene Aliases: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; GPRC1A; GPRC1E; GRM1; GRM5; MGLU1; mGlu5; MGLUR1; MGLUR5; mGluR5b; nmf373; PPP1R85; PPP1R86; rcw; SCA44; SCAR13; wobl

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UniProt ID: (Human) Q13255, (Human) P41594, (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Human) 2911, (Human) 2915, (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071

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Function(s)
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding protein tyrosine kinase binding PLC activating G-protein coupled glutamate receptor activity signal transducer activity estrogen receptor binding calmodulin binding PDZ domain binding G-protein coupled receptor
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission locomotory behavior sensory perception of pain regulation of membrane potential positive regulation of MAPK cascade regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential cellular response to electrical stimulus L-glutamate import across plasma membrane synaptic signaling via neuropeptide regulation of postsynaptic cytosolic calcium ion concentration desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated learning or memory learning regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization positive regulation of calcium-mediated signaling cognition positive regulation of intracellular signal transduction cellular response to beta-amyloid activation of MAPKK activity activation of MAPK activity protein kinase C-activating G-protein coupled receptor signaling pathway calcium-mediated signaling dimeric G-protein coupled receptor signaling pathway regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of glutamate secretion membrane depolarization synaptic transmission, GABAergic activation of MAPKKK activity protein phosphorylation negative regulation of locomotion phosphatidylinositol-mediated signaling
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