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Fig4/Sac3 Monoclonal Antibody (N202/7)

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Fig4/Sac3 Monoclonal Antibody (N202/7)

Product Details

75-201

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N202/7

Immunogen

Fusion protein amino acids 688-907 of mouse Sac3 (accession number Q91WF7) produced recombinantly in E. Coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; KIAA0274; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; Serine-protein phosphatase FIG4; unnamed protein product

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Gene Aliases: A530089I17Rik; AI326867; ALS11; BOP; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; SAC3; YVS

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UniProt ID: (Human) Q92562, (Mouse) Q91WF7

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Entrez Gene ID: (Human) 9896, (Mouse) 103199

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Function(s)
phosphatidylinositol-3-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity protein serine/threonine phosphatase activity protein binding hydrolase activity phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol bisphosphate phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity phosphohistidine phosphatase activity inositol bisphosphate phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity phosphoric ester hydrolase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity phosphatase
Process(es)
phosphatidylinositol biosynthetic process vacuole organization locomotory behavior positive regulation of neuron projection development negative regulation of myelination myelin assembly phosphatidylinositol-3-phosphate biosynthetic process myelination pigmentation phosphatidylinositol metabolic process phosphatidylinositol dephosphorylation neuron development dephosphorylation
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