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GABA-A-R-Gamma2L Monoclonal Antibody (N452/69), FL490
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Product Details
75-442-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N452/69
Immunogen
Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (accession number P18507-2) produced recombinantly in E. Coli.
Conjugate
FL490
FL490
FL490
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
GABA-A-R-Gamma2L refers to the long splice variant of the gamma2 subunit of the GABA-A receptor, which is a major inhibitory neurotransmitter receptor in the central nervous system. The gamma2 subunit is critical for the receptor's proper assembly, trafficking, and synaptic localization, and it influences the receptor's pharmacological properties, including its sensitivity to benzodiazepines. Mutations or alterations in the gamma2 subunit, including the gamma2L variant, can affect inhibitory neurotransmission and are associated with neurological disorders such as epilepsy and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid type A receptor gamma 2 subunit; gamma-aminobutyric acid type A receptor gamma2 subunit; unnamed protein product
Gene Aliases: CAE2; DEE74; ECA2; EIEE74; FEB8; GABAA-R; Gabrg-2; gamma2; GEFSP3
UniProt ID: (Human) P18507, (Mouse) P22723, (Rat) P18508
Entrez Gene ID: (Human) 2566, (Mouse) 14406, (Rat) 29709
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
protein binding
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GABA receptor activity
inhibitory extracellular ligand-gated ion channel activity
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
post-embryonic development
adult behavior
ion transmembrane transport
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
cellular response to zinc ion
cellular response to histamine
response to anesthetic
chloride transmembrane transport
inhibitory synapse assembly
response to ethanol
negative regulation of synaptic transmission, GABAergic
extrasynaptic signaling via GABA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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