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Alomone Labs, LTD
KCNN4 (KCa3.1, SK4) (extracellular) Monoclonal Antibody (6C1), FITC
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FIGURE: 1 / 2
KCNN4 (KCa3.1, SK4) (extracellular) Antibody (ALM-051-F-50UG) in Flow
Cell surface detection of KCNN4 in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + mouse IgM isotype control-FITC. (green) Cells + Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular)-FITC Antibody (#ALM-051-F), (2.5 µg).
Product Details
ALM-051-F-50UG
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
6C1
Immunogen
Synthetic mapping to the 3rd extracellular loop of human KCNN4, 3rd extracellular loop of human KCNN4 (207-227, 265-285).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µg double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gardos channel; HIK1; hKCa4; IK1; IKCa; IKCa1; intermediate conductance calcium-activated potassium channel; Intermediate conductance calcium-activated potassium channel protein 4; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCa3.1; KCa4; KCNN 4; KCNN4; mIK1; mKCa4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4
Gene Aliases: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; KCNN4; mIKCa1; rKCNN4c; rSK4; SK4; SKCa4; SKCas
UniProt ID: (Human) O15554, (Mouse) O89109
Entrez Gene ID: (Human) 3783, (Rat) 65206, (Mouse) 16534
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
voltage-gated ion channel
immune system process
ion transport
potassium ion transport
calcium ion transport
cell volume homeostasis
defense response
stabilization of membrane potential
ion transmembrane transport
macropinocytosis
phospholipid translocation
saliva secretion
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
regulation of transport
protein homotetramerization
establishment of localization in cell
regulation of biological quality
potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
regulation of calcium ion import across plasma membrane
anion transport
potassium ion export
transport
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