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ATG5 Polyclonal Antibody
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Product Details
OSA00021W-150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse ATG5 conjugated to blue carrier protein has been used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: ATG5.
Target Information
ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APG 5; APG5; APG5 autophagy 5 like (APG5L); APG5-like; Apoptosis-specific protein (ASP); AT5G17290; ATATG5; ATG5; ATG5 autophagy related 5 homolog; AUTOPHAGY 5; Autophagy protein 5; autophagy-related 5; MKP11.20; MKP11_20
Gene Aliases: 2010107M05Rik; 3110067M24Rik; Apg5l; Atg5; Atg5l; AW319544; C88337; Paddy
UniProt ID: (Mouse) Q99J83, (Rat) Q3MQ06
Entrez Gene ID: (Mouse) 11793, (Rat) 365601
autophagosome assembly
mitophagy
blood vessel remodeling
immune system process
regulation of cytokine secretion involved in immune response
C-terminal protein lipidation
autophagy
apoptotic process
cellular response to nitrogen starvation
response to fungus
negative regulation of protein ubiquitination
negative stranded viral RNA replication
vasodilation
response to drug
negative regulation of apoptotic process
post-translational protein modification
nucleophagy
innate immune response
otolith development
regulation of release of sequestered calcium ion into cytosol
ventricular cardiac muscle cell development
heart contraction
positive regulation of mucus secretion
regulation of cilium assembly
positive regulation of mitophagy
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process
negative regulation of histone H4-K16 acetylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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