Invitrogen

CD11b Monoclonal Antibody (M1/70), Super Bright™ 780, eBioscience™

Product Image Gallery

CD11b Antibody in Flow Cytometry (Flow) — BALB/c mouse bone marrow cells were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.06 µg of Rat IgG2b kappa Isotype Control, Super Bright 780 (Product # 78-4031-82) (left) or 0.06 µg of CD11b Monoclonal Antibody, Super Bright 780 (right). Total viable cells were used for analysis.

CD11b Antibody in Immunocytochemistry (ICC/IF) — 10.1371/journal.pone.0255296.g003 Fig 3 Chronodisruption causes increased macrophage and microglial signaling in the placenta. Placentas from ( A-C ) control light (CL) and mice exposed to ( D-F ) developmental chronodisruption (CD) were labeled for inflammatory markers labeling microglia and macrophages within the decidual zone. In placenta from CD mice increased placental ( G ) Iba1 fluorescence (Student's 2-tailed unpaired t-test, t = 2.49, df = 8, p = 0.038) and increased placental (H ) CD11b fluorescence (Student's 2-tailed unpaired t-test, t = 2.70, df = 8, p = 0.027) were detected. CL = 4 placenta from different dams, 3 images each; CD = 6 placenta from different dams, 3 images each. All data are presented as mean +- SEM, scale bar = 20 microns, and * = p<0.05.

CD11b Antibody in Immunocytochemistry, Immunohistochemistry (PFA fixed) (ICC/IF, IHC (PFA)) — Figure 3 Histochemical analysis of eye cross-sections show reduced rates of inflammatory cell infiltration and swelling of the cornea in Serp-1 treated mice. (A) Histochemical analysis of eye cross-sections shows reduced rates of inflammatory cell infiltration and swelling of the cornea in Serp-1 treated mice. Enlarged images of the corneal region of two mice visibly show more swelling and a higher presence of inflammatory cells in the control mice. Inflammatory cell nuclei are stained by the deep-purple spots marked with white triangles in the light pink stromal layer of the cornea. (B) To further identify infiltrating immune cells, the slides were stained with CD11b (an immune cell marker, green). (C) CD11b positive cells (cells/0.1 mm 2 ) were quantified ( n = 3/group; * p < 0.05).

CD11b Antibody in Immunohistochemistry (Frozen) (IHC (F)) — Figure 5 Expression of IL-16 by CNS resident cells in EAE mice. Spinal cord and brain tissues were harvested from EAE and PBS control mice and stained with IL-16 (green) together with NeuN, GFAP or CD11b (all red). Representative images of spinal cord ( A - C ) and hippocampus ( D ) tissues are shown. Dotted white lines indicate tissue section edges. White arrows indicate areas of colocalisation. Percentage of double-positive cells in each group within either the spinal cord ( A - C ) or hippocampus ( E - G ) and cerebellum ( H - J ) was quantified with results expressed as the mean +- SEM. N = 5. Statistical significance was determined by one-way ANOVA with Bonferroni post hoc tests. * p < 0.05, ** p < 0.01, *** p < 0.001 versus PBS or comparison groups are indicated by the bar lines.

CD11b Antibody in Immunohistochemistry (IHC) — 4 FIGURE Deciphering the diversity of myeloid cells in infected lung lesions. (A) Uniform manifold approximation and projection (UMAP) plot of the defined myeloid cell subsets in the six samples. (B) UMAP plot of the myeloid cell subsets in the three groups. (C) Bar plot showing the relative proportions of identified cell populations in each sample, colored according to cluster designation. Identified cell types are shown on the right. (D) Dotplot of the top expressed genes distinctly within the subclusters of myeloid cells. Avg. Exp: average expression; % of Exp: percent of expression. (E) Immunofluorescence (IF) of neutrophils with 4',6-diamidino-2-phenylindole (DAPI) (blue) and myeloperoxidase (MPO) (red) colored among the three groups is shown. Magnification: 20x. Scale bar = 100 mum. (F and G) Multiplex immunohistochemistry (mIHC) showing coexpression of CD11c (green), Siglec-F (red), and DAPI (blue)-positive cells called alveolar macrophages (AMs) (F) and CD11b (green), Mertk (red), and DAPI (blue)-positive cells called interstitial macrophages (IMs) (G) among the three groups. Magnification: 20x. Scale bar = 100 mum. (H-J) Representative flow cytometry plots and quantification showing the proportional changes in neutrophils (H), AMs (I), and IMs (J) in the three groups. (K) Histograms showing the proportion of neutrophils, AMs and IMs among the three groups ( n = 3). Bars represent mean +- SD. Significant differences were designated by using analysis of variance (

CD11b Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow) — Fig. 3 ZD55-IL-24 inhibits melanoma growth in B16-bearing immunocompetent mouse model mainly through the indirect pathway of inducing systemic antitumor immunity. A , B Changes of the immune-related cytokines in tumors treated with ZD55-IL-24. A Heat-map of the down-regulated immunosuppressive cytokines in Fig. 2 C . B Heat-map of the up-regulated immunostimulatory cytokines in Fig. 2 D . C - J Immunohistochemical analysis of immune cell infiltration in tumors, as well as recruitment and activation in spleens. Tumors and spleens resected from B16-bearing C57BL/6 mice receiving PBS or ZD55-IL-24 treatment indicated in Fig. 1 A were analyzed 2 days after the last injection by immunohistochemical staining. C Shown are representative images of tumor sections immunostained for CD8 (red, left panel), CD11b and Ly-6G (yellow, middle panel), and NK1.1 (red, right panel). D Quantification of the CD8 + cells in C ( n = 11). E Quantification of the CD11b + Ly-6G + Ly-6C low neutrophils in C ( n = 3). f Quantification of the NK1.1 + cells in c ( n = 6). G Quantification of the CD8 + cells in H ( n = 9). H Shown are representative images of spleen sections immunostained for CD8 (red, left panel), CD11b and Ly-6G (yellow, middle panel), and NK1.1 (red, right panel). I Quantification of the CD11b + Ly-6G + Ly-6C low neutrophils in H ( n = 3). j Quantification of NK1.1 + cells in h ( n = 9). Nuclei is counterstained with DAPI (blue). Data are mean +- SD. Scale bars, 300 um. Shown is one of t

CD11b Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry (PFA fixed)

CD11b Antibody in Western Blot (WB) — Gene expression profile and Western blot analysis of four out of the 50 most differentially regulated genes ( CEBPD , PFKL , GPR75 , and ITGAM ) in all hLECs populations. Actin was used as the loading control. Graphs show the differences in CEBPD, PFKL, GPR75, and ITGAM expression between SPM/ST hLECs and LPM/ST hLECs. p -value: * < 0.08.

Product Details

78-0112-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

0.125 µg/test

View 97 publications 97 publications

Neutralization (Neu)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), Super Bright™ 780, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

M1/70

Conjugate

Super Bright™ 780

Excitation/Emission Max

413/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

RRID

AB_2722926

Product Specific Information

Description: The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDa integrin alphaM. CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.

Applications Reported: This M1/70 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This M1/70 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Super Bright 780 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 780 nm. We recommend using a 780/60 bandpass filter. Please make sure that your instrument is capable of detecting this fluorochrome.

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.

In some experiments, we have observed that compensation values for Super Bright 780-conjugated antibodies are higher in the violet 450/50 channel when using UltraComp eBeads microspheres (Product # 01-2222-42) as compared to single-color stained cells. In such circumstances, we would recommend setting compensation with cells. We have also observed this in some experiments using AbC Total Antibody Compensation beads (Product # A10497).

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 405 nm; Emission: 780 nm; Laser: Violet Laser

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Flow Cytometry

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Product References

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Frontiers in pharmacology

Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H

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Thu Feb 02 00:00:00 EST 2023

Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen.

Glia

Garrido-Gil P,Pedrosa MA,Garcia-Garrote M,Pequeño-Valtierra A,Rodríguez-Castro J,García-Souto D,Rodríguez-Pérez AI,Labandeira-Garcia JL

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Thu Dec 01 00:00:00 EST 2022

Single-cell transcriptomics reveals distinct cell response between acute and chronic pulmonary infection of Pseudomonas aeruginosa.

MedComm

Hu X,Wu M,Ma T,Zhang Y,Zou C,Wang R,Zhang Y,Ren Y,Li Q,Liu H,Li H,Wang T,Sun X,Yang Y,Tang M,Li X,Li J,Gao X,Li T,Zhou X

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.

Experimental & molecular medicine

Seo SH,Kim E,Yoon M,Lee SH,Park BH,Choi KY

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis.

Bioactive materials

Jiao D,Wang J,Yu W,Zhang K,Zhang N,Cao L,Jiang X,Bai Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells.

Cells

Le-Bel G,Desjardins P,Gross C,Cortez Ghio S,Couture C,Germain L,Guérin SL

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Western Blot

Wed Aug 31 00:00:00 EDT 2022

Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.

Journal of clinical & cellular immunology

Alkhateeb T,Bah I,Kumbhare A,Youssef D,Yao ZQ,McCall CE,Gazzar ME

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat Aug 13 00:00:00 EDT 2022

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Frontiers in cardiovascular medicine

Ju B,Guo O,Benissan-Messan DZ,Shawver MH,Chen P,Geng B,Wei S,Yaron JR,Lucas AR,Zhu H

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry (PFA fixed)

Fri May 20 00:00:00 EDT 2022

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Frontiers in cardiovascular medicine

Ju B,Guo O,Benissan-Messan DZ,Shawver MH,Chen P,Geng B,Wei S,Yaron JR,Lucas AR,Zhu H

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry (PFA fixed)

Fri May 20 00:00:00 EDT 2022

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

Nature communications

Franklin R,Guo Y,He S,Chen M,Ji F,Zhou X,Frankhouser D,Do BT,Chiem C,Jang M,Blanco MA,Vander Heiden MG,Rockne RC,Ninova M,Sykes DB,Hochedlinger K,Lu R,Sadreyev RI,Murn J,Volk A,Cheloufi S

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Apr 29 00:00:00 EDT 2022

Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy.

Journal of inflammation research

Wang S,Cui Y,Xiong M,Li M,Wang P,Cui J,Du X,Chen Y,Zhang T

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Sat Apr 23 00:00:00 EDT 2022

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

Nature communications

Schmid MC,Kang SW,Chen H,Paradise M,Ghebremedhin A,Kaneda MM,Chin SM,Do A,Watterson DM,Varner JA

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.

Cellular and molecular gastroenterology and hepatology

Delvecchio FR,Fincham REA,Spear S,Clear A,Roy-Luzarraga M,Balkwill FR,Gribben JG,Bombardieri M,Hodivala-Dilke K,Capasso M,Kocher HM

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Mar 28 00:00:00 EDT 2022

Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.

Cellular and molecular gastroenterology and hepatology

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Fri Mar 25 00:00:00 EDT 2022

Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

PLoS neglected tropical diseases

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Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

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Mon Jan 24 00:00:00 EST 2022

Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.

Nature communications

Dai B,Xu J,Li X,Huang L,Hopkins C,Wang H,Yao H,Mi J,Zheng L,Wang J,Tong W,Chow DH,Li Y,He X,Hu P,Chen Z,Zu H,Li Y,Yao Y,Jiang Q,Qin L

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

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A Population of M2 Macrophages Associated With Bone Formation.

Frontiers in immunology

Olmsted-Davis E,Mejia J,Salisbury E,Gugala Z,Davis AR

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Dec 13 00:00:00 EST 2021

Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.

Frontiers in immunology

Alam J,de Paiva CS,Pflugfelder SC

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Dec 10 00:00:00 EST 2021

Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression.

Bioengineered

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M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.

Journal of nanobiotechnology

Wang Y,Gong X,Li J,Wang H,Xu X,Wu Y,Wang J,Wang S,Li Y,Zhang Z

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Neutralization

Sat Nov 27 00:00:00 EST 2021

Developmental chronodisruption alters placental signaling in mice.

PloS one

Clarkson-Townsend DA,Bales KL,Hermetz KE,Burt AA,Pardue MT,Marsit CJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunocytochemistry

Wed Nov 24 00:00:00 EST 2021

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PloS one

Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Nov 17 00:00:00 EST 2021

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.

The Journal of reproduction and development

Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Aug 27 00:00:00 EDT 2021

Platelet-Like Fusogenic Liposome-Mediated Targeting Delivery of miR-21 Improves Myocardial Remodeling by Reprogramming Macrophages Post Myocardial Ischemia-Reperfusion Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tan H,Song Y,Chen J,Zhang N,Wang Q,Li Q,Gao J,Yang H,Dong Z,Weng X,Wang Z,Sun D,Yakufu W,Pang Z,Huang Z,Ge J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.

Aging

Wang B,Li J,Jiao J,Xu M,Luo Y,Wang F,Xia Q,Gao Y,Feng Y,Kong X,Sun X

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Jul 21 00:00:00 EDT 2021

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.

Frontiers in immunology

Hsu CY,Lin YC,Chang LY,Huang SK,Huang CH,Yang CK,Huang CT,Lin CY

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jun 15 00:00:00 EDT 2021

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.

Nature communications

Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

CD36 deficiency ameliorates drug-induced acute liver injury in mice.

Molecular medicine (Cambridge, Mass.)

Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sun Jun 06 00:00:00 EDT 2021

Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.

Biology

Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry (Frozen)

Thu May 27 00:00:00 EDT 2021

Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity.

Journal of immunology research

Antonucci L,Porcu C,Timperi E,Santini SJ,Iannucci G,Balsano C

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri May 21 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunocytochemistry

Mon May 17 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunocytochemistry

Mon May 17 00:00:00 EDT 2021

Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.

Physiological reports

Miura I,Komine S,Okada K,Wada S,Warabi E,Uchida F,Oh S,Suzuki H,Mizokami Y,Shoda J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.

Frontiers in immunology

Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Apr 12 00:00:00 EDT 2021

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.

JCI insight

Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Apr 08 00:00:00 EDT 2021

The effects of postmortem delay on mouse and human microglia gene expression.

Glia

Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice.

Investigative ophthalmology & visual science

Clarkson-Townsend DA,Bales KL,Marsit CJ,Pardue MT

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.

Frontiers in immunology

Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Mar 29 00:00:00 EDT 2021

Mycobacterium tuberculosis Load in Host Cells and the Antibacterial Activity of Alveolar Macrophages Are Linked and Differentially Regulated in Various Lung Lesions of Patients with Pulmonary Tuberculosis.

International journal of molecular sciences

Ufimtseva EG,Eremeeva NI,Umpeleva TV,Vakhrusheva DV,Skornyakov SN

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Mar 26 00:00:00 EDT 2021

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Nature communications

Fujino T,Goyama S,Sugiura Y,Inoue D,Asada S,Yamasaki S,Matsumoto A,Yamaguchi K,Isobe Y,Tsuchiya A,Shikata S,Sato N,Morinaga H,Fukuyama T,Tanaka Y,Fukushima T,Takeda R,Yamamoto K,Honda H,Nishimura EK,Furukawa Y,Shibata T,Abdel-Wahab O,Suematsu M,Kitamura T

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

In vitro and ex vivo evaluation of tumor-derived exosome-induced dendritic cell dysfunction in mouse.

STAR protocols

Zeng W,Yin X,Jiang Y,Jin L,Liang W

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension.

British journal of pharmacology

Wang L,Zhang X,Cao Y,Ma Q,Mao X,Xu J,Yang Q,Zhou Y,Lucas R,Fulton DJ,Su Y,Barman SA,Hong M,Liu Z,Huo Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

Cell host & microbe

Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Feb 10 00:00:00 EST 2021

Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint.

Cells

Nazet U,Feulner L,Muschter D,Neubert P,Schatz V,Grässel S,Jantsch J,Proff P,Schröder A,Kirschneck C

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Jan 01 00:00:00 EST 2021

Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack.

BioMed research international

Jiang JK,Hong LJ,Lu YQ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System.

Biomedicines

Hong Y,Singh N,Bamopoulos S,Gjerga E,Schmalbrock LK,Balabanian K,Schick M,Keller U,Wirth M

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.

eLife

Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing.

Cell death & disease

Hu HJ,Liang X,Li HL,Du CM,Hao JL,Wang HY,Gu JF,Ni AM,Sun LY,Xiao J,Hu JQ,Yuan H,Dai YS,Jin XT,Zhang KJ,Liu XY

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Nov 30 00:00:00 EST 2020

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing.

Cell death & disease

Hu HJ,Liang X,Li HL,Du CM,Hao JL,Wang HY,Gu JF,Ni AM,Sun LY,Xiao J,Hu JQ,Yuan H,Dai YS,Jin XT,Zhang KJ,Liu XY

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Nov 30 00:00:00 EST 2020

Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.

Stem cell research & therapy

Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Nov 27 00:00:00 EST 2020

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b⁺Ly6G^- myeloid cells.

Aging

Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Nov 24 00:00:00 EST 2020

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Nov 20 00:00:00 EST 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Nov 20 00:00:00 EST 2020

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.

Cells

Iannotta L,Biosa A,Kluss JH,Tombesi G,Kaganovich A,Cogo S,Plotegher N,Civiero L,Lobbestael E,Baekelandt V,Cookson MR,Greggio E

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Thu Oct 22 00:00:00 EDT 2020

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma.

Cancers

Shirley SA,Lundberg CG,Heller R

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Wed Oct 21 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

The EMBO journal

Liu Z,Xu E,Zhao HT,Cole T,West AB

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunocytochemistry

Thu Oct 15 00:00:00 EDT 2020

Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice.

Journal of cardiovascular pharmacology

Jia K,Dai Y,Liu A,Li X,Wu L,Lu L,Bao Y,Jin Q

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Thu Oct 01 00:00:00 EDT 2020

Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.

Journal of leukocyte biology

Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells.

Scientific reports

Rai V,Wood MB,Feng H,Schabla NM,Tu S,Zuo J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Sep 16 00:00:00 EDT 2020

Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.

Glia

Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.

Cancers

Kuziel G,Thompson V,D'Amato JV,Arendt LM

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jul 28 00:00:00 EDT 2020

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.

PLoS biology

Li J,Zhao Y,Choi J,Ting KK,Coleman P,Chen J,Cogger VC,Wan L,Shi Z,Moller T,Zheng X,Vadas MA,Gamble JR

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry (PFA fixed)

Mon Jun 01 00:00:00 EDT 2020

Irradiation induces cancer lung metastasis through activation of the cGAS-STING-CCL5 pathway in mesenchymal stromal cells.

Cell death & disease

Zheng Z,Jia S,Shao C,Shi Y

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu May 07 00:00:00 EDT 2020

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Apr 29 00:00:00 EDT 2020

Ly6c^Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Apr 28 00:00:00 EDT 2020

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Arteriosclerosis, thrombosis, and vascular biology

Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.

British journal of pharmacology

De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Nature

Zhang B,Ma S,Rachmin I,He M,Baral P,Choi S,Gonçalves WA,Shwartz Y,Fast EM,Su Y,Zon LI,Regev A,Buenrostro JD,Cunha TM,Chiu IM,Fisher DE,Hsu YC

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Wed Jan 01 00:00:00 EST 2020

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.

Nature communications

Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.

Nature communications

Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Sep 13 00:00:00 EDT 2019

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.

PLoS biology

Gharagozloo M,Mahmoud S,Simard C,Yamamoto K,Bobbala D,Ilangumaran S,Smith MD,Lamontagne A,Jarjoura S,Denault JB,Blais V,Gendron L,Vilariño-Güell C,Sadovnick AD,Ting JP,Calabresi PA,Amrani A,Gris D

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2019

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.

Autophagy

Qiang L,Sample A,Shea CR,Soltani K,Macleod KF,He YY

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Jul 05 00:00:00 EDT 2019

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Nature neuroscience

Lloyd AF,Davies CL,Holloway RK,Labrak Y,Ireland G,Carradori D,Dillenburg A,Borger E,Soong D,Richardson JC,Kuhlmann T,Williams A,Pollard JW,des Rieux A,Priller J,Miron VE

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.

Cellular and molecular gastroenterology and hepatology

Cipriani G,Terhaar ML,Eisenman ST,Ji S,Linden DR,Wright AM,Sha L,Ordog T,Szurszewski JH,Gibbons SJ,Farrugia G

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells.

Journal of cellular physiology

Siavashi V,Nassiri SM,Rahbarghazi R,Mohseni Z,Sharifi AM

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.

Scientific reports

Kimura H,Imura YK,Tomiyasu H,Mihara T,Kaji N,Ohno K,Unno T,Tanahashi Y,Jan TR,Tsubone H,Ozaki H,Hori M

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Apr 10 00:00:00 EDT 2019

Chemokine Receptor Redundancy and Specificity Are Context Dependent.

Immunity

Dyer DP,Medina-Ruiz L,Bartolini R,Schuette F,Hughes CE,Pallas K,Vidler F,Macleod MKL,Kelly CJ,Lee KM,Hansell CAH,Graham GJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Feb 19 00:00:00 EST 2019

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.

Nature immunology

Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2019

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages.

British journal of pharmacology

Feng L,Sun Y,Song P,Xu L,Wu X,Wu X,Shen Y,Sun Y,Kong L,Wu X,Xu Q

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.

Glia

Borggrewe M,Grit C,Den Dunnen WFA,Burm SM,Bajramovic JJ,Noelle RJ,Eggen BJL,Laman JD

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity.

Journal of immunology (Baltimore, Md. : 1950)

De Leon-Rodriguez CM,Rossi DCP,Fu MS,Dragotakes Q,Coelho C,Guerrero Ros I,Caballero B,Nolan SJ,Casadevall A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Sun Jul 15 00:00:00 EDT 2018

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

The Journal of clinical investigation

Lau A,Chung H,Komada T,Platnich JM,Sandall CF,Choudhury SR,Chun J,Naumenko V,Surewaard BG,Nelson MC,Ulke-Lemée A,Beck PL,Benediktsson H,Jevnikar AM,Snelgrove SL,Hickey MJ,Senger DL,James MT,Macdonald JA,Kubes P,Jenne CN,Muruve DA

78-0112 was used in Flow cytometry/Cell sorting to show that CI-AKI is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.

Mon Jul 02 00:00:00 EDT 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.

Journal of neuroimmunology

McLane VD,Kumar S,Leeming R,Rau S,Willis CL,Cao L

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunohistochemistry

Fri Jun 15 00:00:00 EDT 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.

Nature communications

Clemente C,Rius C,Alonso-Herranz L,Martín-Alonso M,Pollán Á,Camafeita E,Martínez F,Mota RA,Núñez V,Rodríguez C,Seiki M,Martínez-González J,Andrés V,Ricote M,Arroyo AG

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Neutralization

Fri Mar 02 00:00:00 EST 2018

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Journal of the American Society of Nephrology : JASN

Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.

Journal of cellular biochemistry

Vafaei R,Nassiri SM,Siavashi V

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment.

Acta ophthalmologica

Bignami F,Lorusso A,Rama P,Ferrari G

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.

Proceedings of the National Academy of Sciences of the United States of America

Bao Y,Wu X,Chen J,Hu X,Zeng F,Cheng J,Jin H,Lin X,Chen LF

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

Ethanol, TLR3, and TLR4 Agonists Have Unique Innate Immune Responses in Neuron-Like SH-SY5Y and Microglia-Like BV2.

Alcoholism, clinical and experimental research

Lawrimore CJ,Crews FT

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

ECM-Dependence of Endothelial Progenitor Cell Features.

Journal of cellular biochemistry

Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor.

Journal of cellular physiology

Li Y,Adomat H,Guns ET,Hojabrpour P,Duronio V,Curran TA,Jalili RB,Jia W,Delwar Z,Zhang Y,Elizei SS,Ghahary A

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Immunocytochemistry

Wed Jun 01 00:00:00 EDT 2016

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

Glia

Verheijden S,Beckers L,Casazza A,Butovsky O,Mazzone M,Baes M

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma.

Cancer research

Chen X,Zhang L,Zhang IY,Liang J,Wang H,Ouyang M,Wu S,da Fonseca ACC,Weng L,Yamamoto Y,Yamamoto H,Natarajan R,Badie B

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Dec 15 00:00:00 EST 2014

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang H,Zhang L,Zhang IY,Chen X,Da Fonseca A,Wu S,Ren H,Badie S,Sadeghi S,Ouyang M,Warden CD,Badie B

Published figure using CD11b monoclonal antibody (Product # 78-0112-82) in Flow Cytometry

Mon Jul 15 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: CD11 antigen-like family member B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; integrin alpha-M; leukocyte adhesion receptor MO1; Mac-1 alpha; Mac-1 alpha (Mac1A); macrophage antigen alpha; MGC117044

Gene Aliases: Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1

Entrez Gene ID: (Mouse) 16409

Molecular Function: integrin

Function(s)

leukocyte migration involved in inflammatory response cell adhesion leukocyte cell-cell adhesion integrin-mediated signaling pathway microglia development single organismal cell-cell adhesion neutrophil chemotaxis cellular extravasation activated T cell proliferation

Process(es)

opsonin binding glycoprotein binding heparin binding heparan sulfate proteoglycan binding metal ion binding protein heterodimerization activity

CD11b Monoclonal Antibody (M1/70), Super Bright™ 780, eBioscience™

Product Details

78-0112-82

Western Blot (WB)

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Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

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