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Product Details
MA5-28221
| Applications | Tested Dilution | Publications |
|---|---|---|
Flow Cytometry (Flow) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse |
Host/Isotype |
Rat / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
L5-B8.2A12.3A12 |
Immunogen |
Mouse TREM-1 Fc fusion protein |
Conjugate |
PE
|
Excitation/Emission Max |
565/576 nm
View spectra
|
Form |
Lyophilized |
Concentration |
Conc. Not Determined |
Purification |
Protein G |
Storage buffer |
PBS with 1% BSA, 5% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
4° C, store in dark, DO NOT FREEZE! |
RRID |
AB_2745191 |
Product Specific Information
Reconstitute with 1.0 mL distilled water
Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes.
Target Information
TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Flow Cytometry
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Bioinformatics
Protein Aliases: CD354; sCD354; soluble CD354; soluble TREM 1; soluble TREM1; sTREM 1; sTREM1; TREM; TREM-1; triggering receptor expressed in monocytes 1; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 1
Gene Aliases: Trem1
UniProt ID: (Mouse) Q9JKE2
Entrez Gene ID: (Mouse) 58217
positive regulation of defense response to virus by host
cytokine secretion involved in immune response
cell migration
neutrophil chemotaxis
cytokine metabolic process
chemokine metabolic process
neutrophil mediated killing of gram-negative bacterium
neutrophil extravasation
mitophagy in response to mitochondrial depolarization
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