|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis.
MHCD0428TR was used in flow cytometry to describe the CD6(hi)TRAV-2(+) TCR repertoire.
|Held K,Beltrán E,Moser M,Hohlfeld R,Dornmair K||Human immunology (76:607)||2015|
High content cellular immune profiling reveals differences between rhesus monkeys and men.
MHCD0428TR was used in flow cytometry to use flow cytometry to compare the composition of the human and rhesus macaques cellular immune system
|Magalhaes I,Vudattu NK,Ahmed RK,Kühlmann-Berenzon S,Ngo Y,Sizemore DR,Wehlin L,Weichold F,Andersson J,Skeiky YA,Sadoff J,Gaines H,Thorstensson R,Spångberg M,Maeurer MJ||Immunology (131:128)||2010|