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OriGene
Sox17 Monoclonal Antibody (OTI2G8), TrueMAB™
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Product Details
CF500096
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI2G8
Immunogen
Human recombinant protein fragment corresponding to amino acids 177-414 of human SOX17 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 17; SRY-box 17; SRY-related HMG-box transcription factor SOX17; Transcription factor SOX-17; unnamed protein product
Gene Aliases: PPH7; SOX17; VUR3
UniProt ID: (Human) Q9H6I2
Entrez Gene ID: (Human) 64321, (Dog) 486955
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
HMG box transcription factor
angiogenesis
vasculogenesis
metanephros development
endoderm formation
endodermal cell fate specification
inner cell mass cellular morphogenesis
heart looping
cardiogenic plate morphogenesis
embryonic heart tube morphogenesis
outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
gastrulation
endoderm development
endodermal cell fate determination
heart development
tissue development
gene expression
positive regulation of gene expression
Wnt signaling pathway
rostrocaudal neural tube patterning
signal transduction involved in regulation of gene expression
negative regulation of Wnt signaling pathway
negative regulation of cell growth
protein destabilization
embryonic heart tube development
endodermal cell differentiation
cell migration involved in gastrulation
response to alkaloid
regulation of cell differentiation
positive regulation of protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
embryonic organ development
embryonic foregut morphogenesis
anatomical structure formation involved in morphogenesis
stem cell differentiation
stem cell fate specification
protein stabilization
endocardium formation
cardiac cell fate determination
heart formation
endocardial cell differentiation
common bile duct development
gall bladder development
endodermal digestive tract morphogenesis
regulation of stem cell proliferation
ureter development
negative regulation of canonical Wnt signaling pathway
positive regulation of endodermal cell differentiation
cellular response to leukemia inhibitory factor
regulation of stem cell division
regulation of cardiac cell fate specification
positive regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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