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Proteintech
E-cadherin Monoclonal Antibody (6B11F11), CoraLite® 555
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Product Details
CL555-60335
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
6B11F11
Immunogen
E-cadherin fusion protein Ag15085
Conjugate
Excitation/Emission Max
555/570 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PIFNPTTYK GQVPENEANV VITTLKVTDA DAPNTPAWEA VYTILNDDGG QFVVTTNPVN NDGILKTAKG LDFEAKQQYI LHVAVTNVVP FEVSLTTSTA TVTVDVLDVN EAPIFVPPEK RVEVSEDFGV GQEITSYTAQ EPDTFMEQKI TYRIWRDTAN WLEINPDTGA ISTRAELDRE DFEHVKNSTY TALIIATDNG SPVATGTGTL LLILSDVNDN APIPEPRTIF FCERNPKPQV INIIDADLPP I
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; cell-CAM 120/80; E-cadherin; E-cadherin 1; Ecadherin; epididymis secretory sperm binding protein; Epithelial cadherin; unnamed protein product; Uvomorulin
Gene Aliases: Arc-1; BCDS1; CD324; CDH1; CDHE; E-cadherin; ECAD; LCAM; UVO
UniProt ID: (Human) P12830
Entrez Gene ID: (Human) 999, (Pig) 100048953
calcium ion binding
protein binding
beta-catenin binding
ankyrin binding
GTPase activating protein binding
identical protein binding
gamma-catenin binding
cadherin binding
metal ion binding
cell adhesion molecule binding
protein binding involved in cell-cell adhesion
protein tyrosine kinase binding
cadherin
cell morphogenesis
desmosome assembly
cell-cell junction assembly
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
synapse assembly
response to xenobiotic stimulus
response to toxic substance
regulation of gene expression
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
pituitary gland development
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of axon extension
neuron projection development
cell junction assembly
adherens junction organization
positive regulation of protein import into nucleus
cell-cell adhesion mediated by cadherin
positive regulation of transcription, DNA-templated
regulation of transport
cellular response to lithium ion
response to heparin
cellular response to indole-3-methanol
protein localization to plasma membrane
cell-cell adhesion
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
response to Gram-positive bacterium
positive regulation of cellular protein localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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