Immunogen sequence: IVSVNTLVLG HSEPGEASFL PCSSQSSEES SRQSCMSVPG MSTGTVLGAG SIGTDIANEI LD
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
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Protein Aliases: aryl hydrocarbon receptor nuclear translocator-like 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; Brain and muscle ARNT-like 2; Class E basic helix-loop-helix protein 6; CLIF; CYCLE-like factor; Member of PAS protein 9; MGC149671; MGC149672; PAS domain-containing protein 9; transcription factor BMAL2
Gene Aliases: ARNTL2; BHLHE6; BMAL2; CLIF; MOP9; PASD9
UniProt ID: (Human) Q8WYA1
Entrez Gene ID: (Human) 56938