PA5-28622 targets CrkL in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-28622 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 282 of Human CrkL.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
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Protein Aliases: Crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
Gene Aliases: 1110025F07Rik; AA589403; AI325100; CRKL; Crkol