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Invitrogen
FIR Polyclonal Antibody
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FIGURE: 1 / 2
FIR Antibody (PA5-36136) in WB
Western blot analysis of FIR in Lane 1: SGC7901 whole cell lysate (40 µg), Lane 2: HEK293T whole cell lysate (40 µg), Lane 3: PC12 whole cell lysate (40 µg), Lane 4: AML-12 whole cell lysate (40 µg). Samples were incubated with FIR polyclonal antibody (Product # PA5-36136) at a dilution of 1:1,000.
Product Details
PA5-36136
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 341-390 of human FIR
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 120 kDa.
Purity is >95% by SDS-PAGE.
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FERM domain including RhoGEF; FERM domain-including RhoGEF; FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FGD1-related Cdc42-GEF; FIR; PH domain-containing family C member 3; Pleckstrin homology domain-containing family C member 3
Gene Aliases: AI465173; BC009153; D030026M03Rik; FARP2; FIR; FRG; KIAA0793; mKIAA0793; PLEKHC3
UniProt ID: (Human) O94887, (Mouse) Q91VS8
Entrez Gene ID: (Human) 9855, (Mouse) 227377, (Rat) 316639
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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