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Proteintech
Frizzled 2 Polyclonal Antibody
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Product Details
24272-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Frizzled 2 Fusion Protein Ag18003 (138-217 aa encoded by BC113402)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CEHFPRHGA EQICVGQNHS EDGAPALLTT APPPGLQPGA GGTPGGPGGG GAPPRYATLE HPFHCPRVLK VPSYLSYKFL G (138-217 aa encoded by BC113402)
Target Information
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dfrizzled2; Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled 2, seven transmembrane spanning receptor; frizzled family receptor 2; frizzled homolog 2; Frizzled-10; Frizzled-2; Fz-10; Fz-2; FzE2; mFz2; polarity gene; putative; rFz2
Gene Aliases: AL033370; AW456835; Fz-10; fz-2; Fz10; Fz2; Fzd10; FZD2; fzE2; hFz2; Mfz10; Mfz10a; OMOD2
UniProt ID: (Human) Q14332, (Rat) Q08464, (Mouse) Q9JIP6
Entrez Gene ID: (Human) 2535, (Rat) 64512, (Mouse) 57265
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
sensory perception of smell
Wnt signaling pathway
neuron differentiation
non-canonical Wnt signaling pathway
endothelial cell differentiation
positive regulation of transcription, DNA-templated
hard palate development
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor cell development
ventricular septum morphogenesis
cochlea morphogenesis
cell activation
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
Wnt signaling pathway, calcium modulating pathway
multicellular organism development
positive regulation of cGMP metabolic process
epithelial cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to vitamin D
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
planar cell polarity pathway involved in neural tube closure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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