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Agrisera
GORK/Potassium channel GORK Polyclonal Antibody
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Product Details
AS14-2795
Product Specifications
Species Reactivity
Plant
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
KLH-conjugated peptide derived from Arabidopsis thaliana GORK protein.
Conjugate
Form
Lyophilized
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
Target Information
GORK encodes a plant Shaker-type, voltage-gated K+ channel that localizes predominantly to the plasma membrane of guard cells (and is also detected in peripheral puncta consistent with membrane microdomain clustering), where it provides the major outward-rectifying K+ conductance enabling K+ efflux during stomatal closure. The channel is built as a tetramer of pore-forming subunits; each subunit contains an N-terminal cytosolic region, six transmembrane helices (S1-S6) with a canonical re-entrant pore loop between S5 and S6 that confers high K+ selectivity, and a cytosolic C-terminal regulatory region. Recent structural work shows that the C terminus includes a C-linker coupled to a cyclic nucleotide-binding homology domain (CNBHD) and an ankyrin-repeat domain, with conformational rearrangements across this cytosolic module proposed to tune gating. Functionally, GORK mediates depolarization-activated, outwardly rectifying K+ currents and exhibits K+-dependent gating, properties that help ensure net K+ release when the electrochemical driving force favors efflux; loss-of-function or dominant-negative interference suppresses guard-cell outward K+ currents and perturbs stomatal movement and transpiration control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT5G37500; gated outwardly-rectifying K+ channel; MPA22.4; MPA22_4
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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