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Invitrogen
JMJD2D Polyclonal Antibody
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Product Details
PA5-34882
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human KDM4D. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (88%), Rat (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The JMJD2D gene encodes a member of the Jumonji C domain-containing histone demethylases, which are involved in the epigenetic regulation of gene expression by demethylating lysine residues on histone proteins. JMJD2D specifically interacts with β-catenin and is implicated in colorectal cancer, where it activates transcription of target genes and promotes cell proliferation, migration, and tumor formation. Structurally, JMJD2D belongs to the JMJD2 family but exhibits distinct features, lacking certain regions that make it the most structurally divergent within the family. Additionally, JMJD2D stabilizes and cooperates with the hepatitis B virus protein HBx, facilitating cccDNA transcription by demethylating H3K9me3 and counteracting the repressive effects of p53. JMJD2D's role in various cellular processes highlights its importance in both cancer pathogenesis and viral replication, making it a potential target in therapeutic research for colorectal cancer and hepatitis B.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(9) demethylase 4D; FLJ10251; JmjC domain-containing histone demethylation protein 3D; jumonji domain containing 2D; Jumonji domain-containing protein 2D; lysine (K)-specific demethylase 4D; Lysine-specific demethylase 4D
Gene Aliases: JHDM3D; JMJD2D; KDM4D
UniProt ID: (Human) Q6B0I6
Entrez Gene ID: (Human) 55693
double-strand break repair via homologous recombination
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
histone H3-K9 demethylation
positive regulation of chromatin binding
oxidation-reduction process
cellular response to ionizing radiation
positive regulation of double-strand break repair via nonhomologous end joining
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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