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KCNN4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-6675R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human KCNN4, amino acids 325-427.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gardos channel; HIK1; IK1; IKCa; intermediate conductance calcium-activated potassium channel; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCa4; KCNN 4; KCNN4; Kcnn4; SK4; Kcnn4a; Kcnn4b; Kcnn4c; mKCa4; KCNN4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4; smooth muscle intermediate-conductance KCa channel; unnamed protein product
Gene Aliases: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1; mKCa4; rIK1; rKCNN4c; rSK4; SK4; SKCa4; SKCas; SMIK
UniProt ID: (Human) O15554, (Mouse) O89109
Entrez Gene ID: (Human) 3783, (Mouse) 16534, (Rat) 65206
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
inward rectifier potassium channel activity
regulation of angiotensin levels in blood
cardiac muscle hypertrophy
potassium ion transport
calcium ion transport
anion transport
cell volume homeostasis
negative regulation of cardiac muscle hypertrophy
stabilization of membrane potential
regulation of tumor necrosis factor production
macropinocytosis
phospholipid translocation
negative regulation of cell volume
saliva secretion
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
regulation of protein secretion
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
protein homotetramerization
positive regulation of G0 to G1 transition
regulation of monocyte chemotactic protein-1 production
mononuclear cell migration
potassium ion transmembrane transport
hepatocyte apoptotic process
potassium ion export across plasma membrane
regulation of renin secretion into blood stream
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
positive regulation of microglial cell activation
positive regulation of vascular smooth muscle cell proliferation
vascular associated smooth muscle cell migration
positive regulation of vascular associated smooth muscle cell migration
negative regulation of hepatic stellate cell proliferation
regulation of calcium ion import across plasma membrane
response to hypoxia
response to insulin
cellular response to hypoxia
response to tetrachloromethane
vascular associated smooth muscle cell proliferation
defense response
regulation of transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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