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Proteintech
KCNN4 Polyclonal Antibody, CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-23271
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNN4 fusion protein Ag19774
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VQDLGAPLT SPQPWPGFLG QGEALLSLAM LLRLYLVPRA VLLRSGVLLN ASYRSIGALN QVRFRHWFVA KLYMNTHPGR LLLGLTLGLW LTTAWVLSVA ERQAVNATGH LSDTLWLIPI TFLTIGYGDV VPGTMWGKIV CLCTGVMGVC CTALLVAVVA RKLEFNKAEK HVHNFMMDIQ YTKEMKESAA RVLQEAWMFY KHTRRKESHA ARRHQRKLLA AINAFRQVRL KHRKLREQVN SMVDISKMHM ILYDLQQNLS SSHRALEKQI DTLAGKLDAL TELLSTALGP RQLPEPSQQS K
Target Information
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gardos channel; HIK1; IKCa; intermediate conductance calcium-activated potassium channel; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCNN 4; KCNN4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; putative Gardos channel; small conductance calcium-activated potassium channel 4
Gene Aliases: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; SK4; SKCa4
UniProt ID: (Human) O15554
Entrez Gene ID: (Human) 3783
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
potassium ion transport
calcium ion transport
defense response
stabilization of membrane potential
macropinocytosis
positive regulation of T cell receptor signaling pathway
regulation of transport
protein homotetramerization
potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
regulation of calcium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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