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Invitrogen
CD203c Monoclonal Antibody (NP4D6)
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FIGURE: 1 / 2
CD203c Antibody (MA1-10138) in Flow
Separation of CD203c positive basophil granulocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of IgE stimulated human peripheral whole blood using anti-human CD203c (NP4D6) purified Monoclonal antibody (Product # MA1-10138); concentration in sample 2 µg/mL, GAM APC.
Product Details
MA1-10138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
NP4D6
Immunogen
HEK-293 cells transfected with human CD203c
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an extracellular epitope of CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Target Information
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alkaline phosphodiesterase I; CD203c; Dinucleoside polyphosphatase; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); E-NPP 3; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; ENPP3; gp130RB13-6; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; PD-Ibeta; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; phosphodiesterase-I beta; unnamed protein product
Gene Aliases: B10; CD203c; ENPP3; NPP3; PD-IBETA; PDNP3
UniProt ID: (Human) O14638
Entrez Gene ID: (Human) 5169
nucleic acid binding
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
phosphodiesterase I activity
calcium ion binding
zinc ion binding
pyrophosphatase activity
hydrolase activity
bis(5'-adenosyl)-pentaphosphatase activity
GTP diphosphatase activity
UTP diphosphatase activity
metal ion binding
nucleoside-triphosphate diphosphatase activity
ATP diphosphatase activity
bis(5'-adenosyl)-triphosphatase activity
basophil activation involved in immune response
pyrimidine nucleotide metabolic process
phosphate-containing compound metabolic process
nucleoside triphosphate catabolic process
inorganic diphosphate transport
negative regulation of mast cell activation involved in immune response
ATP metabolic process
negative regulation of inflammatory response
phosphate ion homeostasis
negative regulation of mast cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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