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HLA-DR1 Monoclonal Antibody (MEM-267), PE
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FIGURE: 1 / 3
HLA-DR1 Antibody (MA1-10354) in Flow
Separation of human HLA-DR1 (empty) positive HLA-DR positive cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human HLA-DR1-empty (MEM-267) PE Monoclonal antibody (Product # MA1-10354) (concentration in sample 9 µg/mL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-10354
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
MEM-267
Immunogen
Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
Target Information
HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DRB52; FLJ75017; FLJ76359; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen heavy chain; HLA-DR-alpha chain precursor; HLA-DR-beta chain; HLA-DRA; HLA-DRB1; human leucocyte antigen DRB1; lymphocyte antigen DRB1; MHC class II antigen DRA; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product; XXbac-BPG161M6.1
Gene Aliases: DRB1; HLA-DR1B; HLA-DRA1; HLA-DRB; SS1
UniProt ID: (Human) P01903, (Human) P01911
Entrez Gene ID: (Human) 3122, (Human) 3123
positive regulation of T cell mediated cytotoxicity
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of memory T cell differentiation
regulation of T-helper cell differentiation
positive regulation of immune response
positive regulation of T cell activation
cognition
positive regulation of CD4-positive, alpha-beta T cell activation
inflammatory response to antigenic stimulus
positive regulation of T cell mediated immune response to tumor cell
negative regulation of inflammatory response to antigenic stimulus
humoral immune response
cytoskeleton organization
signal transduction
epidermis development
detection of bacterium
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of monocyte differentiation
T cell receptor signaling pathway
protein tetramerization
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