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Invitrogen

HLA-DR1 Monoclonal Antibody (MEM-267)

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HLA-DR1 Monoclonal Antibody (MEM-267)

Product Details

MA1-19393

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

MEM-267

Immunogen

Purified, insoluble DR1 beta chain, expressed in E. coli inclusion bodies.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1076828

Product Specific Information

This antibody binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

For Flow cytometry: The antibody stains immature dendritic cells that express empty cell surface MHC molecules, but not cells that express predominantly peptide loaded forms.

Target Information

HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DRB52; FLJ75017; FLJ76359; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen heavy chain; HLA-DR-alpha chain precursor; HLA-DR-beta chain; HLA-DRA; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; lymphocyte antigen DRB1; MHC class II antigen DRA; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product; XXbac-BPG161M6.1

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Gene Aliases: DRB1; HLA-DR1B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; SS1

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UniProt ID: (Human) P01903, (Human) P01911

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Entrez Gene ID: (Human) 3122, (Human) 3123

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Function(s)
protein binding MHC class II protein complex binding polysaccharide binding MHC class II receptor activity peptide antigen binding T cell receptor binding structural constituent of cytoskeleton CD4 receptor binding
Process(es)
positive regulation of T cell mediated cytotoxicity adaptive immune response immune system process myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of memory T cell differentiation regulation of T-helper cell differentiation positive regulation of immune response positive regulation of T cell activation cognition positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of protein phosphorylation inflammatory response to antigenic stimulus positive regulation of T cell mediated immune response to tumor cell negative regulation of inflammatory response to antigenic stimulus humoral immune response cytoskeleton organization signal transduction epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of kinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell T cell receptor signaling pathway protein tetramerization positive regulation of ERK1 and ERK2 cascade
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