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Invitrogen

HSP90 Monoclonal Antibody (AC-16), APC

View all (36) HSP90 antibodies

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Product Details

MA5-45115

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:2,000
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Chicken, Fungi, Human, Insect, Mouse, Plant, Rabbit, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

AC-16

Immunogen

Heat shock protein 90 from the water mold Achyla ambisexualis

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931569

Product Specific Information

1 µg/mL of MA5-45115 was sufficient for detection of HSP90 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody|Detects 90kDa. This antibody is reactive with both the constitutive and the inducible form of HSP90. It does not bind to the native form and does not recognize HSP90 from E.coli or yeast.

Target Information

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 90kDa heat shock protein; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP84; HSP86; hsp90 beta; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen; unnamed protein product

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Gene Aliases: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; Hsp103; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPC3; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2

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UniProt ID: (Chicken) P11501, (Human) P07900, (Human) P08238, (Rabbit) P30947, (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Chicken) 423463, (Human) 3320, (Rabbit) 100338694, (Chicken) 396188, (Human) 3326, (Rabbit) 100358690, (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252

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Function(s)
ATP binding protein C-terminus binding ATPase activity nitric-oxide synthase regulator activity estrogen receptor binding TPR domain binding heat shock protein binding progesterone receptor binding identical protein binding virion binding unfolded protein binding chaperone binding Hsp90 protein binding disordered domain specific binding nucleotide binding UTP binding CTP binding RNA binding mRNA binding protein binding GTP binding hydrolase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding ubiquitin protein ligase binding dATP binding protein homodimerization activity histone deacetylase binding protein binding involved in protein folding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding DNA polymerase binding scaffold protein binding ATP-dependent protein folding chaperone enzyme-substrate adaptor activity protein tyrosine kinase binding protein dimerization activity double-stranded RNA binding protein kinase regulator activity kinase binding protein kinase binding peptide binding ATP-dependent protein binding cadherin binding protein phosphatase activator activity receptor ligand inhibitor activity histone methyltransferase binding poly(A) RNA binding Hsp90 family chaperone
Process(es)
protein folding positive regulation of cell proliferation response to heat response to cold response to organonitrogen compound response to organic cyclic compound response to progesterone cellular response to heat positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity protein stabilization positive regulation of cell cycle G2/M phase transition neuron migration activation of innate immune response positive regulation of defense response to virus by host skeletal muscle contraction mitochondrial transport response to unfolded protein telomere maintenance via telomerase response to xenobiotic stimulus response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process protein import into mitochondrial matrix regulation of protein ubiquitination positive regulation of telomere maintenance via telomerase positive regulation of protein polymerization positive regulation of interferon-beta production regulation of protein localization protein refolding response to cocaine positive regulation of protein import into nucleus regulation of apoptotic process regulation of protein complex assembly protein unfolding response to estrogen positive regulation of protein catabolic process positive regulation of cell size nitric oxide metabolic process chaperone-mediated protein complex assembly positive regulation of cardiac muscle contraction chaperone-mediated autophagy cellular response to virus regulation of postsynaptic membrane neurotransmitter receptor levels neurofibrillary tangle assembly telomerase holoenzyme complex assembly positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of cell cycle arrest negative regulation of transforming growth factor beta activation placenta development virion attachment to host cell negative regulation of apoptotic process positive regulation of cell differentiation regulation of cell cycle cellular response to interleukin-4 fibril organization negative regulation of proteasomal protein catabolic process positive regulation of protein localization to cell surface nitric oxide biosynthetic process response to stress positive regulation of protein import into nucleus, translocation protein import into mitochondrial outer membrane positive regulation of cytotoxic T cell differentiation positive regulation of protein binding negative regulation of neuron apoptotic process positive regulation of protein serine/threonine kinase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to organic cyclic compound
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