Immunogen sequence: TNLIVTPNQRQ NVCAENEGIP DGACSKDSDC HAGEAVTAGN GVKTGRCLRR ENLARGTCEI FAWCPLETSS RPEEPFLKE
Highest antigen sequence identity to the following orthologs - mouse 74%, rat 74%.
BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5; ATP receptor; ATP receptor subunit; ionotropic ATP receptor P2X5; ligand-gated ion channel; lymphoid-restricted histocompatibility antigen-1; MGC47755; P2X purinoceptor 5; P2X5; P2X5R; Purinergic receptor; Purinergic receptor P2X; purinergic receptor P2X, ligand gated ion channel, 5; purinergic receptor P2X, ligand-gated ion channel, 5
Gene Aliases: LRH-1; P2RX5; P2X5; P2X5R
UniProt ID: (Human) Q93086
Entrez Gene ID: (Human) 5026