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Fabgennix
PDE4A Polyclonal Antibody
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FIGURE: 1 / 1
PDE4A Antibody (PD4A-112AP) in IHC
IF of PD4A-112AP with thick section of mouse nose tissue. Green: Olfactory sensory neurons. Red: Antibody immunoreactivity. Blue: Nuclei. PD4A-112AP labels olfactory sensory neurons in mouse nasal epithelia. Data provided by Dr. Kroos lab Caltech, Pasadena, CA.
Product Details
PD4A-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase PDE4A; cyclic AMP (cAMP)-specific phosphodiesterase; cyclic AMP specific phosphodiesterase family 4 sub-family A isoform 11; cyclic AMP specific phosphodiesterase PDE4A5A; DPDE2; dunce; PDE46; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; type-IVA cyclic AMP specific phosphodiesterase HPDE4A
Gene Aliases: D9Ertd60e; DPDE2; PDE4; PDE46; PDE4A; PHOSA
UniProt ID: (Human) P27815, (Mouse) O89084, (Rat) P54748
Entrez Gene ID: (Human) 5141, (Mouse) 18577, (Rat) 25638
cAMP catabolic process
signal transduction
G-protein coupled receptor signaling pathway
sensory perception of smell
cellular response to xenobiotic stimulus
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cAMP/PKA signal transduction
negative regulation of cAMP/PKA signal transduction
regulation of protein kinase A signaling
cellular response to drug
regulation of cAMP-mediated signaling
metabolic process
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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