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Bioreactors

Single-use bioreactor—designed for performance and scalability

Enable superior performance and automation with Thermo Scientific Single-Use Bioreactor systems (S.U.B.). Developed with proven technology and design features created to improve speed-to-market, scalability and sustainability. Our versatile portfolio of S.U.B.s support robust production across scales and have the flexibility to accommodate a variety of cell lines and processing modalities.

 

Our bioreactor systems have been used in laboratories worldwide for nearly 20 years, and we have a global network of bioprocessing specialists available for support—offering efficient, reliable, and scalable solutions across process development and production operations.

Bioreactors for a variety of applications

DynaDrive single-use bioreactor

DynaDrive single-use bioreactor ranging in sizes from 5 L to 5,000 L

Straightforward scalability and trusted performance

HyPerforma single-use bioreactor

HyPerforma single-use bioreactor ranging in sizes from 50 L to 2,000 L

Trusted and reliable results

Single-use rocker bioreactor

Single-use rocker bioreactor ranging in sizes from 10 L to 50 L

For process development and sensitive cell lines

Experience the innovation of DynaDrive S.U.B. now available at 5 L for process development.

Sign up to receive an application note and learn more 

Video series: What makes DynaDrive technology different than others?

Versatile HyPerforma Glass Bioreactors for efficient mixing and easy operation


HyPerforma Glass Bioreactors are available in 1 L, 3 L, 7 L, and 15 L sizes. They offer easy operation and rapid assembly and are manufactured with the highest standards for materials and surface finish. Developed using a computational fluid dynamics (CFD) simulator, the HyPerforma Glass Bioreactor impellers facilitate maximum mixing with minimum shear force, resulting in a higher average kLa.

Bioreactor automation software and controllers

Data Integrity Optimization

Our bioprocess automation and software optimize data integrity during scale-up and tech transfer allowing you to use historical data in your scaled-up processes.
 

Scalable Process Control

Thermo Scientific bioprocess controllers facilitate easy data transfer, process optimization, and scalability by incorporating innovative features that enhance productivity, quality, and reproducibility.
 

Flexible Process Monitoring

Our bioprocess controllers are highly configurable and able to integrate trusted single-use or autoclavable sensors. Monitor and control product environments with robust data collection that will aid in scale-up from process development through production.

High-quality bioreactor consumables

Advanced single-use containers are the basis of single-use bioprocessing equipment. Experience reliability and biocompatibility with Thermo Scientific S.U.B. bags and consumables. 

  • Made with robust Thermo Scientific Aegis5-14 film, offering exceptional reliability and backed by decades of experience
  • Experience consistent cell culture performance from small to large volumes with the same film technology across the workflow from bioreactor bags to media bags
  • Minimize the risk of leaks and simplify setup with the Thermo Scientific BioTitan Retention Device, an innovative replacement for traditional cable ties that enhances the reliability and integrity of assemblies with a 360° seal
  • Bioreactor bags with demonstrated biocompatibility and low cytotoxicity support healthy cell growth, while low-leachable and extractable profiles support end-product purity and quality

Interested in leasing or financing our equipment?

Manage your resources by taking advantage of financing and leasing options from Thermo Fisher Scientific.

Single-use Bioreactors helping you achieve your sustainability goals

Designed with sustainability in mind, the DynaDrive Single-Use Bioreactor generates up to 27% less product and packaging waste compared to a 2,000 L single-use bioreactor traditional workflow.

Learn more about how you can lower your scope three carbon emissions with our biobased film for bioreactor bags and BPCs.                                                                                                                                                  

Related resources

Application note: Demonstrating bioprocess scalability through platform consistency in DynaDrive Single-Use Bioreactors

Application note: Scale-up evaluation of the DynaDrive S.U.B.s—Part 1: ExpiCHO-S Cells and CHO-S Cells (cGMP banked)  

Brochure: Reimagine scalability  in bioprocessing — The DynaDrive Single-Use Bioreactor (S.U.B.) 


Whitepaper: Enabling high-performing perfusion cell culture                                                                                                                                             

Explore bioprocessing insights


The Bioprocessing Insights Hub by Thermo Fisher Scientific is designed for biomanufacturing professionals, offering educational resources to optimize single-use bioprocessing workflows. It features articles, guides, and case studies on topics such as assembly design, contamination mitigation, and technology transfer. Resources include application notes, brochures, white papers, videos, and webinars, covering areas like process optimization, scalability, quality, and sustainability.

The scalable and compact Thermo Scientific MarqMetrix All-In-One Process Raman Solution consists of an analyzer and probes to help monitor, control, and optimize your processes.

Frequently asked questions

Bioreactors are used to culture cells including mammalian (e.g. CHO, CHO-K1), insect, yeast, and bacterial to produce therapeutic proteins, monoclonal antibodies, nanobodies, vaccines, and gene therapies.

Benchtop bioreactors support smaller volumes and include glass, rocker (or wave), and small single-use bioreactors. Glass bioreactors (1 –15 L) are re-usable and are compatible with suspension and adherent cells. Rocker or wave bioreactors typically use single-use bags on a rocker platform; common volumes are 5 – 25 L. For suspension cells, the Thermo Scientific DynaDrive Single-Use Bioreactor 5L is a feature rich benchtop option that easily scales with other DynaDrive Single-Use Bioreactors.

Bioreactors support scale-up by providing a consistent, controlled environment that can be translated from small-scale development to full commercial production. During process development, key parameters—such as pH, dissolved oxygen, temperature and agitation—are optimized at bench scale and then replicated in larger systems using comparable design and control strategies. Modern bioreactors, including the DynaDrive family of single-use bioreactors, are engineered with automation and advanced sensors to maintain similar performance characteristics across volumes.

Mixing, oxygen transfer, turndown ratio, bag quality, controllers, and even tubing connectors can influence bioreactor performance. Mixing and oxygen transfer are important for cell health and consistent results. A high turndown ratio reduces the number of seed train steps improving yields and productivity.  Compatible bags must be of films that are safe for cells with low leachables and extractables. It is also important that the bag manufacturer has a robust and redundant supply chain. Look for details like the  Thermo Scientific BioTitan Rentention Device  which prevents leaks at tubing connection points.

Single-use bioreactors significantly reduce contamination risk since there is no direct contact between the bioprocessing fluids and the bioreactor. They also reduce cleaning steps, leading to faster equipment turnaround time and great lab productivity. Single-use bioreactors are typically smaller and modular, reducing capital equipment expenditures and the need for facility build outs.

For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.