E-Cadherin Mouse Monoclonal Antibody (clone 4A2C7), Concentrate

Catalog number:  180223

 Related applications: Anatomical Pathology

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This monoclonal antibody reacts with human epithelial cadherin (E-cadherin, uvomorulin, Cell-CAM 120/80), a 120 kDa transmembrane glycoprotein. Reduction and/or loss of E-cadherin expression in carcinomas correlates positively with tumor cell invasion and metastasis. Altered expression of E-cadherin is common in the progression of cancers including breast carcinoma, lung carcinoma, gastric tumors, hepatocellular carcinoma, and prostatic tumors. It has recently been reported that E-cadherin is a useful marker for differentiating lobular lesions (negative) from ductal invasive lesions (positive) in breast cancer. Positive tissue: Non-neural epithelia.

Clone/PAD: 4A2C7

Immunogen: Recombinant protein corresponding to the cytoplasmic domain of human E-cadherin

Specificity: Reacts strongly with human E-cadherin and weakly with human P-cadherin.

Reactivity: Human

Applications: Immunohistochemistry (FFPE)

Pretreatment: Epitope Retrieval: Required (Citrate Buffer, pH 6), Enzyme Digestion: Not required

Expected Staining Pattern: Mainly cellular membrane, some cytoplasmic
For In Vitro Diagnostic Use.


Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host Species: Mouse
SubClass (Isotype): IgG1, kappa
Clonality: Monoclonal
Target Gene: E-Cadherin
Gene ID: 999
Label or Dye: Unconjugated
Dilution: Concentrate Antibody
Product Size: 1 mL
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).


Manuals & protocols

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