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Ixekizumab Recombinant Rabbit Monoclonal Antibody (29B12), MonoRab™

View all (207) IL-17A antibodies

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Product Details

A02265-40

Applications
Tested Dilution
Publications

ELISA (ELISA)

0.01-1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

Mammalian cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

29B12

Immunogen

Ixekizumab

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Amount

40 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

Sandwich ELISA recommended dilution: 0.5-2 µg/mL; Competitive ELISA recommended dilution: 1-10 µg/mL

The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; ILN; inflammatory cytokine; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17; Interleukin17A; R-IL-17-A

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Gene Aliases: CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17

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UniProt ID: (Human) Q16552

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Entrez Gene ID: (Human) 3605

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Function(s)
cytokine activity protein binding protein homodimerization activity protein heterodimerization activity
Process(es)
positive regulation of antimicrobial peptide production apoptotic process inflammatory response immune response Notch signaling pathway cell-cell signaling cell death response to wounding gene expression keratinocyte differentiation positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-16 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production interleukin-17A-mediated signaling pathway keratinocyte proliferation positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to fungus intestinal epithelial structure maintenance protein K63-linked ubiquitination fibroblast activation T-helper 17 type immune response interleukin-17-mediated signaling pathway granulocyte migration negative regulation of inflammatory response to wounding positive regulation of cytokine production involved in inflammatory response positive regulation of bicellular tight junction assembly positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of chemokine (C-X-C motif) ligand 1 production
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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