rhLaminin-521

      rhLaminin-521

      Numéro de catalogue:  A29249

      Gibco™

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      Description

      Recombinant human Laminin 521 (rhLaminin-521) is a recombinant human protein that provides a defined surface for feeder-free culture of human pluripotent stem cells (PSCs). When used with Essential 8™ Medium, rhLaminin-521 has been proven to promote cellular survival under stressful conditions in the absence of small molecule inhibitors. rhLaminin-521 has been shown to support PSC growth for >20 passages without any signs of karyotypic abnormalities and to maintain the ability of PSCs to differentiate into all three germ line lineages. rhLaminin-521 also provides optimum reprogramming efficiency of human somatic cells as well as human pluripotent stem cell survival during feeder-dependent to feeder-free transitions when used in conjunction with Essential 8 Medium. For a kit that combines the medium and substrate, see the Essential 8™ Adaptation Kit.

      rhLaminin-521 is:
      • Robust—transition cells between feeder-dependent and feeder-free culture systems with minimal effort
      • Efficient—easily reprogram human fibroblasts to pluripotent stem cells
      • Physiologically relevant—expand cells with minimal differentiation
      • Scalable—passage stem cell lines as single cells with no impact to genetic stability

      Trouble-free transition
      When used with Essential 8 Medium, rhLaminin-521 provides a robust culture matrix that supports pluripotent stem cell adherence and expansion during the transition from feeder-dependent culture systems.

      Efficient reprogramming
      rhLaminin-521 has been shown to increase the number of colonies obtained during reprogramming of human fibroblasts, which can be important for in vitro disease modeling.

      Confident expansion
      rhLaminin-521 is expressed in blastocysts and therefore provides an environment mimicking the human stem cell niche.

      Easy scale-up
      rhLaminin-521 promotes stable pluripotent stem cell maintenance as single cells in the absence of ROCK inhibitors.
      For Research Use Only. Not for use in diagnostic procedures.

      Spécifications

      Shipping Condition: Dry Ice
      Classification: Xeno-Free
      Product Size: 1 mg
      Purity or Quality Grade: hESC-Qualified

      Contenu et stockage

      Store in freezer (-5 to -30°C).

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