Invitrogen™

EGFR (ErbB1) G719S Recombinant Human Protein

Catalog number: A33501
Invitrogen™

EGFR (ErbB1) G719S Recombinant Human Protein

Catalog number: A33501
Catalog Number
A33501
Unit Size
10 µg
Price (USD)
451.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
2,115.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,570.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A3350110 µg
451.00
Your Price:
***
A33555100 µg
2,115.00
Your Price:
***
A337241 mg
6,570.00
Your Price:
***
Product Overview
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Additional Information
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This EGFR (ErbB1) G719S recombinant human protein (695–end) was expressed in insect cells. EGFR receptor tyrosine kinase is a transmembrane glycoprotein. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR (ErbB1) G719S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NP_005219.2
Shipping Condition
Dry Ice
Expression System
Insect
Form
Liquid
Protein Form
Recombinant, Active, Cytoplasmic, Mutant
Species
Human
Validated Application
Kinase Assay
Molecular Weight
84.2 kDa
Quantity
10 µg
KinaseFamily
EGF Receptors (ErbBs)
Protein Length
aa 695 - end
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol

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