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Zitierungen und Referenzen (33)
Invitrogen™
DiFMUP (6,8-Difluoro-4-Methylumbelliferyl Phosphate)
DiFMUP ist ein fluoriertes 4-Methylumbelliferylphosphat(MUP)-Derivat, das einen niedrigeren pKa-Wert als MUP aufweist; dadurch ist DiFMUP ein hervorragendes Substrat für dieWeitere Informationen
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| Katalognummer | Menge |
|---|---|
| D6567 | 5mg |
| D22065 | 10 × 10mg |
Katalognummer D6567
Preis (EUR)
257,65
Exklusiv online
302,00Ersparnis 44,35 (15%)
Each
Menge:
5mg
Preis (EUR)
257,65
Exklusiv online
302,00Ersparnis 44,35 (15%)
Each
DiFMUP ist ein fluoriertes 4-Methylumbelliferylphosphat(MUP)-Derivat, das einen niedrigeren pKa-Wert als MUP aufweist; dadurch ist DiFMUP ein hervorragendes Substrat für die kontinuierliche Bestimmung von sauren Phosphatasen bei niedrigem pH-Wert. Das Reaktionsprodukt von DiFMUP hat Anregungs-/Emissionsmaxima von ∼358/450 nm. DiFMUP ist außerdem in zehn Fläschchen mit je 10 mg (D-22065) erhältlich.
Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.
Specifications
FarbeBlau
Anregung/Emission358⁄455
Zur Verwendung mit (Geräte)Mikrotiterplatten-Lesegerät
Marker oder FarbstoffDiFMU
Menge5mg
VersandbedingungRaumtemperatur
SubstratPhosphatasesubstrat
NachweisverfahrenFluoreszent
FormPulver
Substrate PropertiesChemisches Substrat
Target EnzymePhosphatasen
Unit SizeEach
Inhalt und Lagerung
Im Gefrierschrank lagern (-5 bis -30 °C).
Zitierungen und Referenzen (33)
Zitierungen und Referenzen
Abstract
Surface phosphophilicity of aluminum-containing adjuvants probed by their efficiency for catalyzing the P--O bond cleavage with chromogenic and fluorogenic substrates.
Journal:Anal Biochem
PubMed ID:11476547
'Aluminum-containing adjuvants are widely used in a variety of vaccine products, such as recombinant proteins, virus-like particles, conjugated polysaccharides, and recently DNA vaccines. Aluminum-containing adjuvants are also known to have a high affinity to inorganic phosphate and its mono- or diesters. Since phosphate groups are present in many antigens as
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
Journal:Nat Cell Biol
PubMed ID:15592458
'Integrin-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signalling pathways. So far, integrins have been mainly shown to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signalling. Here we show that a collagen-binding integrin alpha(1)beta(1) functions as a negative regulator of
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Journal:Mol Pharmacol
PubMed ID:16717135
'Shp2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. It is involved in growth factorinduced activation of mitogen-activated protein (MAP) kinases Erk1 and Erk2 (Erk1/2) and has been implicated in the pathogenicity of the oncogenic bacterium Helicobacter pylori. Moreover, gain-of-function Shp2 mutations have been found in
Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects.
Journal:J Cell Biochem
PubMed ID:16514605
'PTP69D is a receptor protein tyrosine phosphatase that was identified as a key regulator of neuromuscular axon guidance in Drosophila, and has subsequently been shown to play a similar role in the central nervous system and retina. Three Ptp69D alleles with mutations involving catalytically important residues exhibit a high degree
High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors.
Journal:Assay Drug Dev Technol
PubMed ID:17939754
'Protein phosphatase type 5 (PP5) belongs to the PPP family of serine/threonine protein phosphatases and is expressed in most, if not all, human tissues. Although the physiological roles played by PP5 are not yet clear, PP5 is found in association with several proteins that influence intracellular signaling networks initiated by