Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)

Citations & References (57)

Invitrogen™

Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)

緑色蛍光フルオレセインメトトレキサート（吸収／最大発光波長：約496⁄516 nm）は、蛍光顕微鏡またはフローサイトメトリーによるジヒドロ葉酸還元酵素（DHFR）発現のプローブとして使用できます。詳細を見る

製品番号（カタログ番号）	数量
M1198MP	1 mg

製品番号（カタログ番号） M1198MP

価格（JPY）

51,300

キャンペーン価格

Ends: 27-Mar-2026

85,600

割引額 34,300 (40%)

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緑色蛍光フルオレセインメトトレキサート（吸収／最大発光波長：約496⁄516 nm）は、蛍光顕微鏡またはフローサイトメトリーによるジヒドロ葉酸還元酵素（DHFR）発現のプローブとして使用できます。

研究用にのみ使用できます。診断用には使用いただけません。

標識タイプ従来の色素

分子式C46H54N14O9S

数量1 mg

推奨保存方法冷凍庫内で保管し（-5～-30℃）、遮光してください。

出荷条件室温

物理的フォームSolid

製品タイプ三アンモニウム塩

Unit SizeEach

引用および参考文献 (57)

引用および参考文献

Abstract

Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.

Authors:Miller DS,Nobmann SN,Gutmann H,Toeroek M,Drewe J,Fricker G

Journal:Molecular pharmacology

PubMed ID:11093774

Visualization of membrane-associated folate transport proteins.

Authors:Pope LE, Fan J, Chang CM, Minskoff SA, Vitols KS, Huennekens FM

Journal:Adv Enzyme Regul

PubMed ID:2516406

'Transport of Methotrexate (MTX) into cells, via the "reduced folate" transport system, is a critical factor in the effectiveness of the drug in cancer chemotherapy, and defective transport is one of the principal types of resistance to MTX. Probes capable of detecting membrane-associated folate transport proteins (ftp''s) in individual cells ... More

MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus).

Authors:Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA,

Journal:Toxicol Sci

PubMed ID:17324950

'We used proximal tubules isolated from the killifish, Fundulus heteroclitus, to examine the effect of environmentally relevant, sublethal levels of arsenic on the function and expression of MRP2, an ABC transporter that transports xenobiotics into urine, including arsenic-glutathione conjugates. Exposure of fish to arsenic as sodium arsenite (4-14 days) increased ... More

Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.

Authors:Assaraf YG, Slotky JI

Journal:J Biol Chem

PubMed ID:8440739

'We describe the characterization of an antitumor drug resistance following multiple step selection of hamster cells to the 2,4-diaminopyrimidines (DAP) metoprine, pyrimethamine (Pyr), and trimethoprim (Tmp). Pyr and Tmp are DAP lipophilic antifolates currently used as antiparasitic and antibacterial antibiotics, respectively. Dihydrofolate reductase (DHFR) from hamster cells bore a low ... More

Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia.

Authors:Trippett T, Schlemmer S, Elisseyeff Y, Goker E, Wachter M, Steinherz P, Tan C, Berman E, Wright JE, Rosowsky A

Journal:Blood

PubMed ID:1381235

'Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little information is available regarding acquired resistance to MTX in patients. A competitive displacement assay using the fluorescent lysine analogue of MTX, N-(4-amino-4-deoxy-N10-methylpteroyl)-N epsilon-(4''-fluorescein-thiocarbamyl)-L-lysine (PT430), was developed as a sensitive method of ... More

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