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Invitrogen
Collagen II Monoclonal Antibody (2B1.5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
.jpg?time=20240507?time=20240507 "Collagen II Antibody (MA1-37493) in ICC/IF")
.jpg?time=20240507?time=20240507 "Collagen II Antibody (MA1-37493) in ICC/IF")
.jpg?time=20240507?time=20240507 "Collagen II Antibody (MA1-37493) in IHC")
Product Details
MA1-37493
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Mouse,
Rat
Published species
Bovine,
Goat,
Guinea pig,
Human,
Mouse,
Pig,
Rabbit,
Rat,
Sheep
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2B1.5
Immunogen
A purified preparation of lathyritic type II collagen from embryonic chicken sternum
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Staining of formalin/parafin tissues requires disgestion of tissue sections with pepsin at 1 mg/mL Tris-HCl, pH 2.0 for 15 min at RT or 10 min at 37C.
Target Information
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 1 type II procollagen; alpha 1 type IIA collagen; alpha collagen type II; alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; CGA; chondrocalcin; COL2A1; Collagen 2; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital); MGC131516; prepro-alpha-1 type II collagen; pro-alpha 1(II); procollagen alpha 1(II); Procollagen II alpha 1; procollagen, type II, alpha 1; T1; type II collagen; unnamed protein product
Gene Aliases: ACG2; ANFH; ANFH1; AOM; CB11; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COLLII; Del1; Dmm; EDMMD; LCPD; Lpk; M100413; OSCDP; PLSDT; Rgsc413; Rgsc856; SEDC; SEDSTN; SEMDSTWK; SMDALG; STL1; VPED
UniProt ID: (Human) P02458, (Bovine) P02459, (Mouse) P28481, (Rat) P05539
Entrez Gene ID: (Human) 1280, (Chicken) 395069, (Bovine) 407142, (Mouse) 12824, (Rat) 25412
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
MHC class II protein binding
identical protein binding
protein homodimerization activity
proteoglycan binding
platelet-derived growth factor binding
metal ion binding
extracellular matrix structural protein
skeletal system development
ossification
chondrocyte differentiation
central nervous system development
visual perception
sensory perception of sound
collagen fibril organization
notochord development
animal organ development
skeletal system morphogenesis
system development
cartilage development
limb bud formation
embryonic skeletal joint morphogenesis
otic vesicle development
extracellular matrix organization
cartilage condensation
tissue homeostasis
endochondral ossification
heart morphogenesis
proteoglycan metabolic process
regulation of gene expression
inner ear morphogenesis
palate development
cartilage development involved in endochondral bone morphogenesis
cellular response to BMP stimulus
anterior head development
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
limb morphogenesis
inner ear development
bone development
growth plate cartilage development
response to mechanical stimulus
response to X-ray
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
response to fibroblast growth factor
cellular response to insulin-like growth factor stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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