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Invitrogen

JAK2 Monoclonal Antibody (1C1)

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JAK2 Monoclonal Antibody (1C1)

Product Details

MA5-15632

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1C1

Immunogen

Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980515

Product Specific Information

MA5-15632 targets JAK2 in indirect ELISA, WB applications and shows reactivity with Human samples.

The MA5-15632 immunogen is purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
.

MA5-15632 detects JAK2 which has a predicted molecular weight of approximately 130.6kDa.

Target Information

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: EC 2.7.10.2; JAK 2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; kinase Jak2; unnamed protein product

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Gene Aliases: JTK10

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UniProt ID: (Human) O60674

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Entrez Gene ID: (Human) 3717

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Function(s)
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein kinase binding heme binding receptor activator activity type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding identical protein binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding peptide hormone receptor binding
Process(es)
microglial cell activation positive regulation of cytokine production immune system process chromatin remodeling apoptotic process response to oxidative stress cell adhesion signal transduction enzyme linked receptor protein signaling pathway positive regulation of cytosolic calcium ion concentration JAK-STAT cascade mesoderm development positive regulation of cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway positive regulation of platelet activation negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion cytokine-mediated signaling pathway regulation of cell-cell adhesion negative regulation of cell-cell adhesion actin filament polymerization cell differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration lipopolysaccharide-mediated signaling pathway mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production response to hydroperoxide tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor post-embryonic hemopoiesis intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-5-mediated signaling pathway collagen-activated signaling pathway interleukin-23-mediated signaling pathway interleukin-3-mediated signaling pathway granulocyte-macrophage colony-stimulating factor signaling pathway erythropoietin-mediated signaling pathway thrombopoietin-mediated signaling pathway oncostatin-M-mediated signaling pathway positive regulation of T cell proliferation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process post-translational protein modification positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation positive regulation of cell adhesion positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of JAK-STAT cascade regulation of alpha-beta T cell activation response to antibiotic protein autophosphorylation platelet-derived growth factor receptor signaling pathway leukemia inhibitory factor signaling pathway regulation of inflammatory response modulation of synaptic transmission positive regulation of cell activation positive regulation of protein kinase B signaling interferon-gamma-mediated signaling pathway positive regulation of SMAD protein import into nucleus growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of growth hormone receptor signaling pathway mammary gland epithelium development interleukin-6-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway positive regulation of leukocyte proliferation response to interleukin-12 interleukin-35-mediated signaling pathway extrinsic apoptotic signaling pathway positive regulation of cold-induced thermogenesis negative regulation of protein localization to chromatin defense response to symbiont negative regulation of cytokine production involved in inflammatory response positive regulation of platelet aggregation positive regulation of intracellular signal transduction positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular smooth muscle cell proliferation regulation of postsynapse to nucleus signaling pathway
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