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Invitrogen
ATG5 Monoclonal Antibody (3C10B6)
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Product Details
MA5-48668
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3C10B6
Immunogen
Purified recombinant fragment of human ATG5 (AA: 144-275) expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; APG 5; APG5; APG5 autophagy 5 like (APG5L); APG5 autophagy 5-like; apoptosis-specific protein; Apoptosis-specific protein (ASP); AT5G17290; ATATG5; ATG5; ATG5 autophagy related 5 homolog; AUTOPHAGY 5; MKP11.20; MKP11_20; similar to S. cerevisiae ATG5 autophagy related 5; unnamed protein product
Gene Aliases: APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25
UniProt ID: (Human) Q9H1Y0
Entrez Gene ID: (Human) 9474
autophagosome assembly
mitophagy
autophagy
cellular response to nitrogen starvation
response to iron(II) ion
positive regulation of autophagy
macroautophagy
negative regulation of type I interferon production
piecemeal microautophagy of nucleus
aggrephagy
negative regulation of apoptotic process
negative regulation of programmed cell death
post-translational protein modification
negative regulation of innate immune response
negative regulation of defense response to virus
chaperone-mediated autophagy
positive regulation of stress granule assembly
cellular response to nitrosative stress
axonal transport
regulation of postsynaptic membrane neurotransmitter receptor levels
postsynaptic modulation of chemical synaptic transmission
regulation of autophagosome maturation
regulation of cilium assembly
response to fluoride
negative regulation of autophagic cell death
positive regulation of viral translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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