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Invitrogen
GRID2 Polyclonal Antibody
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Product Details
PA5-63274
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GRID2. Recombinant protein control fragment (Product #RP-91085).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RVPSKEDDKE IDLEHLHRRV NSLCTDDDSP HKQFSTSSID LTPLDIDTLP TRQALEQISD FRNTHITTTT FIPEQIQTLS RTLSAKAASG FTFGNVPEHR TGPFRHRAPN GGFFRSPIKT MSSIPYQPTP TLGLNLGNDP DR
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; unnamed protein product
Gene Aliases: GluD2; GLURD2; GRID2; SCAR18
UniProt ID: (Human) O43424
Entrez Gene ID: (Human) 2895
AMPA glutamate receptor activity
ion channel activity
protein binding
glutamate receptor activity
ligand-gated ion channel activity
PDZ domain binding
signaling receptor activity
identical protein binding
metal ion binding
scaffold protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glutamate receptor signaling pathway
protein localization
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
regulation of synaptic plasticity
modulation of synaptic transmission
regulation of synapse assembly
positive regulation of synapse assembly
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
prepulse inhibition
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic density assembly
synaptic signaling via neuropeptide
positive regulation of long term synaptic depression
excitatory synapse assembly
regulation of presynapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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