Invitrogen

PABPC1 Polyclonal Antibody

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PABPC1 Polyclonal Antibody

Product Details

PA5-66900

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human PABP. Recombinant protein control fragment (Product #RP-105419).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2662551

Product Specific Information

Immunogen sequence: QTQNRAAYYPP SQIAQLRPSP RWTAQG

Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

Target Information

PABPC1b encodes a poly(A) binding protein|The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs|The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay|The gene is part of a small gene family including three protein-coding genes and several pseudogenes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45; PABP-1; pabpc1; poly A binding protein, cytoplasmic 1 b; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; Polyadenylate-binding protein 1; zgc:77608

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Gene Aliases: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PAB1; PABP; PABP1; PABPC1; PABPC2; PABPL1; PRO2975

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UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752, (Human) P11940

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Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011, (Human) 26986

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Function(s)
endopeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein C-terminus binding poly(A) binding poly(U) RNA binding translation activator activity poly(A) RNA binding protease non-receptor serine/threonine protein kinase
Process(es)
response to hypoxia proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction regulation of autophagy protein processing response to lipopolysaccharide interleukin-1 beta production response to ATP regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response mitochondrial depolarization membrane hyperpolarization pyroptosis cellular response to mechanical stimulus cellular response to organic substance programmed necrotic cell death toxin transport protein phosphorylation phagocytosis Golgi organization mitotic nuclear division cell surface receptor signaling pathway regulation of cell shape Wnt signaling pathway peptidyl-serine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process intermediate filament cytoskeleton organization cell division negative regulation of canonical Wnt signaling pathway regulation of GTP binding beta-catenin destruction complex assembly beta-catenin destruction complex disassembly cell morphogenesis nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening mRNA splicing, via spliceosome mRNA polyadenylation translational initiation gene silencing by RNA regulation of mRNA stability positive regulation of viral genome replication positive regulation of translation mRNA stabilization positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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