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Invitrogen
GRID2 Polyclonal Antibody
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FIGURE: 1 / 2
GRID2 Antibody (PA5-115325) in IHC (P)
Immunohistochemistry analysis of GRID2 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115325) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115325
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRID2(Accession O43424), corresponding to amino acid residues A840-S890.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GRID2.
Target Information
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: creeper; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; glutamate receptor, ionotropic, delta 2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10; unnamed protein product
Gene Aliases:
B230104L07Rik; cpr; GluD2; GluRdelta2; ho; Lc; Lc
UniProt ID: (Human) O43424, (Mouse) Q61625, (Rat) Q63226
Entrez Gene ID: (Human) 2895, (Mouse) 14804, (Rat) 79220
AMPA glutamate receptor activity
ion channel activity
protein binding
glutamate receptor activity
ligand-gated ion channel activity
PDZ domain binding
receptor regulator activity
signaling receptor activity
identical protein binding
scaffold protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
protein localization
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
modulation of synaptic transmission
regulation of synapse assembly
positive regulation of synapse assembly
excitatory postsynaptic potential
prepulse inhibition
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic density assembly
regulation of postsynapse organization
synaptic signaling via neuropeptide
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
positive regulation of long term synaptic depression
excitatory synapse assembly
regulation of presynapse assembly
biological_process
signal transduction
glutamate receptor signaling pathway
regulation of synaptic plasticity
regulation of postsynaptic membrane potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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