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Invitrogen

PLCB1 Polyclonal Antibody

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PLCB1 Polyclonal Antibody

Product Details

PA5-115767

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PLCB1(Accession Q9NQ66), corresponding to amino acid residues G449-P499.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900402

Product Specific Information

Antibody detects endogenous levels of total PLCB1.

Target Information

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C, beta 1 (phosphoinositide-specific); phospholipase C-1; phospholipase C-beta-1a; Phospholipase C-beta1; phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; triphosphoinositide phosphodiesterase; unnamed protein product

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Gene Aliases: 3110043I21Rik; DEE12; EIEE12; mKIAA0581; Phosphb; PI-PLC; PLC'1; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; PLCB1A; PLCB1B; PLCbeta1; RATPHOSPHB

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UniProt ID: (Human) Q9NQ66, (Rat) P10687, (Mouse) Q9Z1B3

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Entrez Gene ID: (Human) 23236, (Rat) 24654, (Mouse) 18795

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Function(s)
phosphatidylinositol phospholipase C activity phospholipase C activity GTPase activator activity calcium ion binding protein binding calmodulin binding lamin binding phosphatidylinositol-4,5-bisphosphate binding phosphoric diester hydrolase activity enzyme binding identical protein binding phosphatidylinositol phospholipase C activity
Process(es)
G2/M transition of mitotic cell cycle lipid metabolic process signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway glutamate receptor signaling pathway learning memory regulation of G-protein coupled receptor protein signaling pathway positive regulation of glycoprotein biosynthetic process lipid catabolic process cerebral cortex development phosphatidylinositol catabolic process positive regulation of interleukin-12 production inositol trisphosphate metabolic process response to monosaccharide intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway positive regulation of embryonic development response to peptide hormone fat cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of JNK cascade phosphatidylinositol metabolic process insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of developmental growth release of sequestered calcium ion into cytosol activation of meiosis involved in egg activation interleukin-1-mediated signaling pathway cellular response to peptide hormone stimulus regulation of fertilization postsynaptic modulation of chemical synaptic transmission regulation of retrograde trans-synaptic signaling by endocanabinoid positive regulation of G1/S transition of mitotic cell cycle cellular response to fluoride regulation of establishment of endothelial barrier cellular response to vasopressin cellular response to ionomycin cellular response to glyceraldehyde positive regulation of acrosome reaction negative regulation of monocyte extravasation oocyte maturation mRNA processing cell adhesion brain development insulin receptor signaling pathway erythrocyte differentiation macrophage differentiation phospholipase C-activating adrenergic receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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