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Invitrogen
HMGA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19197
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KAAQKKAEATGEK) corresponding to the internal amino acids of HMGA2 (aa 62-75).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HMGA2/KRT121P fusion; HMGI-C
Gene Aliases: BABL; HMGI-C; HMGIC; LIPO; SRS5; STQTL9
UniProt ID: (Human) P52926
Entrez Gene ID: (Human) 8091
transcription regulatory region sequence-specific DNA binding
nucleic acid binding
DNA binding
AT DNA binding
transcription cofactor activity
transcription corepressor activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
DNA binding, bending
enzyme binding
nucleosomal DNA binding
cAMP response element binding
MH2 domain binding
MH1 domain binding
SMAD binding
5'-deoxyribose-5-phosphate lyase activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
chondrocyte differentiation
mesodermal-endodermal cell signaling
base-excision repair
chromatin organization
regulation of transcription, DNA-templated
response to virus
regulation of gene expression
regulation of cell cycle process
positive regulation of gene expression
heterochromatin assembly
negative regulation of intracellular steroid hormone receptor signaling pathway
intracellular signal transduction
endodermal cell differentiation
chondrocyte proliferation
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
fat cell differentiation
positive regulation of angiogenesis
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
mesodermal cell differentiation
mesenchymal cell differentiation
stem cell differentiation
positive regulation of cell proliferation in bone marrow
positive regulation of protein serine/threonine kinase activity
oncogene-induced cell senescence
regulation of stem cell population maintenance
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of double-strand break repair via nonhomologous end joining
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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