LIF Proteins

LIF peptides and recombinant proteins are available for Human and Mouse. These Protein have been validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free, GMP and Research... LIF peptides and recombinant proteins are available for Human and Mouse. These Protein have been validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free, GMP and Research Use Only. Gibco and Invitrogen proteins are some of... LIF peptides and recombinant proteins are available for Human and Mouse. These Protein have been validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free, GMP and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. LIF Protein have been referenced in 91 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 9 proteins, including biologically active options. Not finding the exact protein, grade or size needed?... LIF peptides and recombinant proteins are available for Human and Mouse. These Protein have been validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free, GMP and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. LIF Protein have been referenced in 91 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 9 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.

Synonyms

CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor

LIF Proteins

Protein Information

Synonyms

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