This proven, easy-to-implement method combines sample preparation guidelines and a variety of LC-MS options with an extensive mass spectral library for targeted screening, proven methods and intuitive software equipped with customizable reporting templates. It includes application support and training for confident, high quality results.

The compound database and library contain comprehensive information on more than 1,500 compounds of interest and the tested, proven analytical method ensures enhanced confidence in the data quality by eliminating false results, saving both time and cost.

Optimized for quick start-up and ease of use, the Tox Explorer collection is designed to improve efficiency and reduce cost for the analysis of drug compounds in multiple biological matrices with unprecedented speed, ease, and confidence, regardless of user experience level.

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Workstream

 

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Tox Explorer Collection videos

 

Tox Explorer Collection - Inspiring Confidence

Screening, identification and quantitation of an ever-expanding list of drugs can be challenging for toxicology laboratories. LC-MS workstreams enable rapid, accurate, easy-to-use methods to ensure success in toxicology analysis.

Simplifying targeted screening with Orbitrap technology - Making the most of software

Watch a brief demonstration of how TraceFinder software can be used in conjunction with Thermo Scientific mzVault library manager to acquire, monitor, process, review, and report data.

Tox Explorer Collection - Inspiring Confidence

Screening, identification and quantitation of an ever-expanding list of drugs can be challenging for toxicology laboratories. LC-MS workstreams enable rapid, accurate, easy-to-use methods to ensure success in toxicology analysis.

Simplifying targeted screening with Orbitrap technology - Making the most of software

Watch a brief demonstration of how TraceFinder software can be used in conjunction with Thermo Scientific mzVault library manager to acquire, monitor, process, review, and report data.

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LC-MS options

 

Tox Explorer HRAM Solution

High resolution and mass accuracy

Thermo Scientific Orbitrap technology platforms offer high resolution mass spectrometry and better mass accuracy without loss of sensitivity and provide positive/negative polarity switching in one analytical run, saving time and offering greater confidence in data output. Screening, identification, confirmation and quantitation can all be performed on one mass spectrometry platform. One of the key benefits of using high resolution accurate mass (HRAM) mass detection for toxicology analyses is the ability to use retrospective data to help with the identification of novel designer drugs.

  • Screen, identify, confirm, and quantitate – all with one instrument
  • Analyze a broad spectrum of compounds in one run
  • Perform retrospective analysis without requiring additional experiments
  • Obtain comprehensive MS/MS spectra without the need to average, while accessing positive and negative compounds in one run
  • Utilize data-dependent acquisition for the identification of unknown structures via MS/MS spectra
  • Exceptional mass accuracy and stability within and between runs—even at low mass ranges— ensures confidence in results
 Improve efficiency and productivity by capitalizing on an optimal combination of preparation guidelines, outstanding LC, robust MS, intuitive software, an extensive compound library and easy-to-implement methods—all backed by comprehensive training and application support.
 Click image to enlarge

HRAM XIC chromatograms of a select number of analytes ranging from ethyl glucaronide (EtG) to tetrahydrocannabinol (THC). Detection of hydromorphone in full scan mode with mass accuracy of -2.78 ppm, using external calibration. Identification of hydromorphone using MS/MS without averaging scans.

Tox Explorer Platform Components

Part number Description Price (USD)
OPTON-31039 Tox Explorer: HRAM Request a quote ›
   

* Stay up to date on TraceFinder software updates for optimal operation and functionality.

Testimonial

"We have been using mass spectral libraries since 1987 to aid in the identification of mass spectra from full scan and MSn GC-MS, MSn LC-MS and more recently HRAM MS2 LC-MS and have constructed several in house mass spectral libraries. When I talk about mass spectral libraries to non-experts, I liken mass spectra to ‘fingerprints’ for chemicals and in combination with HRAM measurement, the fingerprints become far more specific. Ultimately, the more entries in a mass spectral library the better, and more recently with mzCloud, the information is present for anybody to use.”

Simon Hudson, Technical Director, Laboratory and Managed Services LGC Ltd. Fordham, U.K.

Simon Hudson
Technical Director, Laboratory and Managed Services
LGC Ltd.
Fordham, U.K.

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Resources

 

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Contact us

 

For General Lab Use Only. Not for use in diagnostic procedures.
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