Validated Haloacetic Acids Analysis (HAAs) IC/MS Workflows

Drinking water disinfection by-products by IC-MS/MS

Disinfection is important in ensuring the supply of pathogen-free drinking water. However, excessive consumption of disinfection by-products (DBPs) like haloacetic acids (HAAs), bromate, and dalapon can result in health issues. With increasing regulatory focus on DBPs, drinking water facilities around the world need hands-off, high-throughput analyses of these contaminants.

Accelerate your haloacetic acids, bromate, and dalapon analyses

That's the reason for the Thermo Scientific™ Disinfection By-Products Application Workflow. Comprised of an integrated Thermo Scientific ion chromatography-tandem mass spectrometry (IC-MS/MS) system with direct injection to eliminate sample preparation, this workflow provides rapid, cost-effective drinking water testing per United States Environmental Protection Agency (U.S. EPA) Method 557.

Compared to gas chromatography-electron capture detection (GC-ECD) per U.S. EPA Method 552.3, this workflow does away with time-consuming and complicated manual sample preparation steps. Unlike other IC-MS/MS solutions, Thermo Fisher Scientific manufactures, installs, validates, and services the complete workflow, speeding deployment and maximizing uptime.

Meet global requirements

Meet global requirements

From the United States Safe Drinking Water Act (SDWA), to the European Commission (EC) Right2Water initiatives and emerging regulations in China, government regulations and proposals are driving needs for more efficient DBPs monitoring. The Thermo Scientific DBPs Application Workflow is ideally suited to meet the requirements described by the U.S. EPA and the EC.

Increase sample throughput, reduce costs

Increase sample throughput, reduce costs

There are two EPA methods for HAAs analysis: GC-ECD Method 552.3 and the more recent IC-MS/MS Method 557. Besides differences in the instrument technology used, the methods differ in sample preparation requirements. Time consuming and labor intensive, Method 552.3 requires multiple extraction steps and derivatization exceeding four hours. Method 557 uses direct injection without sample preparation, offering significantly higher sample throughput. For labs running more than 24 batches of 25 samples per month, the DBPs Application Workflow can provide substantial cost savings.

Broaden analytical scope

Broaden analytical scope

U.S. EPA Method 557 can be used to directly determine bromate and dalapon in drinking water samples, broadening analytical scope. One IC-MS/MS system can analyze anionic polar pesticides such as glyphosphate and glufosinate, as well as anionic environmental compounds such as bromide and perchlorate.

Achieve reliable results, meet proficiency standards

Achieve reliable results, meet proficiency standards

Ion chromatography (IC) offers significant benefits for the determination of HAAs due to its ability to efficiently separate polar molecules. Mass spectrometry (MS) detection provides the sensitivity and selectivity required to obtain reliable analytical results using direct injection. Compared to GC-ECD, IC-MS/MS provides better recoveries, making it easier to meet proficiency standards.

A proven workflow, state-of-the-art technology

The DBPs Application Workflow provides proven reliability based on integrated high-performance IC-MS/MS components sold and supported by a single trusted manufacturer. Thermo Fisher Scientific is the only vendor today that provides a complete validated system for DBPs testing per U.S. EPA Method 557. Unlike other systems, the workflow includes proven methods that provide confidence and time savings. To get you up running samples quickly and minimize downtime, the complete system is validated at our factory, and at time of installation and servicing.

A proven workflow, state-of-the-art technology

Water samples can be directly injected into the IC system for separation and subsequent MS/MS detection. Automated data processing and reporting are used to generate results.

Dionex ICS-6000 Standard Bore and Microbore HPIC Systems

The Thermo Scientific Dionex ICS-6000 HPIC system is reliable, economic, and environmentally friendly for the separation of HAAs, bromate, and dalapon. Get significant increases in resolution and throughput, address a full range of IC applications, and solve complex analytical challenges with duality, modularity, capillary/ hybrid operation, and ultimate versatility. The system can operate continuously when configured as a Thermo Scientific Reagent-Free IC (RFIC) System to automate creation of IC eluents and regenerants, reduce labor and solvent costs, and achieve highly reproducible separations.

Conceptual Illustration Surface Modification

Confident quantitation

For highest confidence in quantitation choose the Dionex ICS-6000 HPIC system and the Thermo Scientific TSQ Fortis Triple Quadrupole Mass Spectrometer. The sensitivity provided by these instruments makes it possible to perform direct injection of drinking water samples, eliminating complex and variable sample preparation.

TraceFinder software

TraceFinder software

Simplify high-throughput screening and quantitation. Driven by a powerful and intuitive set of data acquisition and processing tools, the software provides rapid access to results and increases output across the lab. TraceFinder is the software platform familiar to existing MS users and is best suitable for routine, production, and high-throughput laboratories.

Chromeleon CDS software

Chromeleon CDS software

Streamline your workflows. Built with the lab and IT in mind, the software delivers superior compliance tools, networking capabilities, instrument control, automation, data processing, and more. It’s an enterprise solution designed for tracking, accountability, and QA/QC that is incredibly easy to use, with fewer mouse clicks, and more “right-first-time” results. It’s also designed to scale globally and provide strong return on investment.

Dionex ICS-6000 Standard Bore and Microbore HPIC Systems

The Thermo Scientific Dionex ICS-6000 HPIC system is reliable, economic, and environmentally friendly for the separation of HAAs, bromate, and dalapon. Get significant increases in resolution and throughput, address a full range of IC applications, and solve complex analytical challenges with duality, modularity, capillary/ hybrid operation, and ultimate versatility. The system can operate continuously when configured as a Thermo Scientific Reagent-Free IC (RFIC) System to automate creation of IC eluents and regenerants, reduce labor and solvent costs, and achieve highly reproducible separations.

Conceptual Illustration Surface Modification

Confident quantitation

For highest confidence in quantitation choose the Dionex ICS-6000 HPIC system and the Thermo Scientific TSQ Fortis Triple Quadrupole Mass Spectrometer. The sensitivity provided by these instruments makes it possible to perform direct injection of drinking water samples, eliminating complex and variable sample preparation.

TraceFinder software

TraceFinder software

Simplify high-throughput screening and quantitation. Driven by a powerful and intuitive set of data acquisition and processing tools, the software provides rapid access to results and increases output across the lab. TraceFinder is the software platform familiar to existing MS users and is best suitable for routine, production, and high-throughput laboratories.

Chromeleon CDS software

Chromeleon CDS software

Streamline your workflows. Built with the lab and IT in mind, the software delivers superior compliance tools, networking capabilities, instrument control, automation, data processing, and more. It’s an enterprise solution designed for tracking, accountability, and QA/QC that is incredibly easy to use, with fewer mouse clicks, and more “right-first-time” results. It’s also designed to scale globally and provide strong return on investment.

Disinfection by-product formation:

  • The nine major HAAs are formed during chlorination of drinking water containing natural organic matter and bromide
  • Used to address chlorine resistant organisms, ozonation of drinking water containing bromide can result in the formation of bromate, a potential carcinogen even at low μg/L concentrations
  • Dalapon is an herbicide used to control grasses in a wide variety of crop and non-crop applications and can move in water courses by soil erosion. It is associated with minor kidney changes.

The DBP Application Workflow is preferred when there are:

  • Limited time and personnel to perform all analyses required of the laboratory and thus a need to reduce labor intensive tasks, such as liquid-liquid solvent extractions and derivatization
  • Needs for a reliable technique to reduce repeat analyses
  • Multiple inorganic analytes that need testing
  • Faster sample–to–results turn over times are needed
  • Concerns about the use of organic solvents and the associated costs of the chemical waste disposal
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