Nicolet iS50 FTIR Spectrometer overview

Definitive answers for your analytical lab workflows

Solve analytical challenges with ease using the Thermo Scientific Nicolet iS50 FTIR Spectrometer, featuring purpose-built accessories and integrated software—making it an all-in-one materials analysis workstation.


Designed to be highly flexible, the Nicolet iS50 FTIR Spectrometer can be upgraded from a simple FTIR bench to a fully automated, multi-spectral range system that can acquire spectra from far-infrared to visible. You can initiate novel ATR, Raman, and NIR modules at the touch of a button, enabling access to these techniques without manually changing system components.

Nicolet iS50 FTIR Spectrometer features

The Nicolet iS50 FTIR Spectrometer is dual source-capable, offering users both the Polaris long-life IR source and a tungsten-halogen white light source. Full support for a wide range of accessories offers the flexibility you need to target your analysis. Other features of the Nicolet iS50 FTIR Spectrometer include:

  • Three detectors for the main sample compartment
  • High-resolution standard
  • Validation wheel standard
  • All gold optics standard (aluminum available)
  • Neutral-density energy screens mounted on motorized wheel (standard)
  • Optional purge shutters
  • Optional motorized optical filter wheel
  • Optional motorized polarizer
  • Collimated or focused emission port

Nicolet iS50R Research FTIR Spectrometer overview

A state-of-the-art design for advanced materials analysis

Characterize new materials with unmatched flexibility and performance using our Thermo Scientific Nicolet iS50R Research FTIR Spectrometers designed for advanced spectroscopic studies. Modulate amplitude and phase of the signals, and conduct advanced continuous scan, time-resolved step-scan or dual channel spectroscopy applications. Designed with the Vectra-Piezo series interferometer, the Nicolet iS50R PM Spectrometer provides precision and signal-to-noise ratios not possible with air-bearing or mechanical interferometers that are susceptible to laboratory vibrations and acoustic noises.

Nicolet iS50R FTIR Spectrometer features

Equipped with state-of-the-art dual sources, triple detector optics, and multiple on-board digitizers, research spectroscopists will appreciate the precision and flexibility that Nicolet iS50R Research FTIR Spectrometers provide in helping them achieve their advanced research goals. Other features of the Nicolet iS50R FTIR Spectrometer include:

  • Step-Scan Control System and SST Electronics
  • Rapid scanning for fast kinetics
  • 0.09 cm-1 resolution
  • Touch Point one-touch sampling operation
  • Aligned mounting plates front/rear
  • High-speed USB 2.0 interface
  • Built-in, wide-range diamond ATR
  • Compatibility with all Smart Accessories and many others
  • Internal storage for two additional beam splitters

Nicolet iS50 and iS50R FTIR Spectrometer capabilities

Go beyond FTIR analysis with our range of modules and accessories

As your needs grow, so can the capabilities of the Nicolet iS50 spectrometer. Whether you are studying microscopic structures, organic thin films, fast reactions, or new light sources, the Nicolet iS50 spectrometer enables your research now and in the future. Offerings you have come to know, like Thermo Scientific Smart Accessories, are augmented by the following optional modules for both the Nicolet iS50 FTIR Spectrometer and Nicolet iS50R Research FTIR Spectrometer:


Built-in mid- and far-IR capable diamond ATR. Rugged, fast, and always ready to go. Powders, liquids, gels, and pastes can be analyzed, with no setup, using the iS50 ATR. All reflective optics and proprietary detector allow you to analyze organic and inorganic materials with mid- and far-IR spectroscopy. The iS50 ATR leaves the main sample compartment free for other analyses, never requiring you to swap accessories or break system seals.


Automated Beamsplitter Exchanger (ABX). Automate your analysis with the iS50 ABX Automated Beamsplitter Exchanger, which enables the Nicolet iS50 to set up the instrument with a single press of a Touch Point. Now, you can perform the complete analysis including crystallinity, bulk analysis, and identification using near-, mid- and far-IR by loading samples and letting the instrument do the work.


Sample compartment Raman accessory. The Raman accessory provides additional capabilities, like mapping and well-plate screening in a sample compartment-mounted module. Never has laboratory Raman analysis been so versatile, cost effective, and easy-to-use.


NIR module with integrating sphere and fiber optic connections. The NIR module provides integrating sphere and fiber optic options in one compact unit—initiate collection with one touch, run samples through containers without preparation, obtain consistent spectra from heterogeneous solids, and sample solids and liquids in situ.


TGA-IR accessory. Make deformulation a routine procedure for your materials laboratory. Extract more information from your material; get fast, consistent results easily with Mercury TGA software; and probe starting and residual material via ATR to complete the picture.


GC-IR module. Uniquely identify stereochemistry and trace chemicals. Get qualitative, isomer-specific analysis with little effort using the iS50 GC-IR modules and Thermo Scientific OMNIC Mercury GC software. Your productivity can rise further using the industry standard Thermo Scientific Dionex Chromeleon Chromatography Data System software to drive autosamplers and simultaneous GC-FID and GC-IR detection. Add other features of the Nicolet iS50 to create the ultimate forensics laboratory workstation—Raman, ATR and GC—all integrated with the spectrometer.

Whether you’re creating a new API, identifying illicit drugs, or finding a suitable polymer blend, run samples using the Nicolet iS50 FTIR Spectrometer. This all-in-one materials analysis workstation is suitable for the following uses:

  • Polymers and rubbers—run one-touch materials ID, blending, morphology, and kinetics and multi-task in a single workstation
  • Forensics—access two Class-A SWGDRUG methods in a small footprint unit and simplify GC-IR analysis of isomeric materials to one operation
  • Pharmaceuticals—analyze formulations and polymorphs via an integrated system, and validate and deploy QA/QC methods for process or loading-dock use
  • Pigments, paints, and inks—find inorganic fillers and additives in an organic base, and correlate visible colors with formulation
  • Food, flavors, and oils—identify isomeric fragrances and flavors, and analyze moisture, fat, proteins, and extracted oils from seeds
  • General laboratories—bring one-touch consistency to complex analyses and increase laboratory power with many techniques in a small footprint