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In this issue

Chemistry students Kelsey Holbert and Marie Nider from the University of Wisconsin Milwaukee will be giving presentations at this year's Pittcon, demonstrating online reaction monitoring with our Thermo Scientific™ picoSpin™ spectrometers.

Thursday, March 12
Poster Session - A Kinetic Study of the Maillard Reaction by On-Line Monitoring with Sequential Injection-Nuclear Magnetic Resonance Spectroscopy
Session #: 2530
Exposition Floor, Hall F, Aisles 3900-4500

Thursday, March 12, 8:50 a.m.
Oral Session - Development of a Sequential Injection Method for Online Reaction Monitoring by Low-Field Nuclear Magnetic Resonance Spectroscopy
Session #: 2490
Location: 271

Congratulations to John Frost, Jessica Bonjour and Joy Pitzer for their recent publication in the Journal of Chemical Education. The article reviews the implementation of NMR spectroscopy into the (U.S.) high school or first year college undergraduate curriculum. This article presents a simple laboratory experiment using benchtop NMR to determine the percent composition in a series of household solutions explored with high school honors chemistry students.

Read the article

Aspirin (C9H8O4), acetylsalicylic acid, is a salicylate drug used to treat a variety of conditions, including headaches, fever and inflammation. It is also used in low doses in preventive treatment against heart attacks, strokes and blood clots.  

The 1H NMR spectrum of a 4% (w/w; 330 mM) solution of aspirin in chloroform-D was measured at 82 MHz using the Thermo Scientific™ picoSpin™ 80 NMR spectrometer.  

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Flow chemistry is a widely accepted technique in the synthesis field and makes optimization fast and convenient. Using a benchtop NMR instrument allows chemists to measure 1H NMR spectra directly in the fume hood and monitor pseudo real-time behavior of reaction chemistries.

Read this application note from ThalesNano to get details on both the flow synthesis at extremely high temperature as well as the following analysis.

Read the application note

Butanol, C4H9OH, is a high value C4 alcohol collectively represented by fopur isometric structures: 1-butanol, 2-butanol, isobutanol and tert-butanol. Isomers are compounds that have the same molecular formular but which the connectivity of the atoms differ.

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(±)-Propranolol hydrochloride (C16H21NO2 · HCl), a nonselective beta-blocker, is representative of a class of drugs that target the beta receptor. It is prescribed medication for treatment of hypertension, severe headaches, and cardiac related dysrhythmia and ischemia.

The 1H NMR spectrum of a 11.2% (w/w; 420 mM) solution of propranolol in protonated DMSO was measured at 82 MHz using the Thermo Scientific™ picoSpin™ 80 spectrometer.

View this spectrum

About NMR Tech Talk

Featuring the latest news, events, and educational approaches in benchtop NMR, Tech Talk is your forum for bringing this interesting and valuable technique into the classroom or as part of your analytical laboratory. Discover what's new from peers and from our experts at Thermo Fisher Scientific. We welcome your comments and contributions. Email us at info.spectroscopy.us@thermofisher.com

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